动脉粥样硬化模型
- 动脉粥样硬化模型饲料和方法综述
- 大鼠、小鼠造模饲料
- 正常大鼠、小鼠模型饲料
- ◄−−----C57小鼠模型饲料
- 基因工程小鼠模型饲料
- 基因敲除或转基因鼠日常喂养饲料
- ApoE基因敲除(ApoE-/-)小鼠
- LDL受体基因敲除(LDLR-KO)小鼠
- 兔模型饲料
- 地鼠模型饲料
- 豚鼠模型饲料
- 鸽子模型饲料
- 鹌鹑模型饲料
- 鸡模型饲料
- 猪或微型猪模型饲料
- 非人灵长类（猴，等）模型饲料
C57BL/6小鼠
动脉粥样硬化模型造模的高脂高胆固醇模型饲料(纯化型)
High Fat High Cholesterol (HFHC) Diet for Atherosclerosis in C57BL6 Mice
一、C57小鼠动脉粥样硬化模型Paigen饲料(纯化型)
纯化型Paigen饲料（高脂高胆固醇模型饲料）是C57小鼠动脉粥样硬化模型造模（复制）最广泛使用的动脉粥样硬化模型造模模型饲料。
1.纯化型Paigen饲料的优势
(1)纯化型Paigen模型饲料是Paigen等研究者对脂肪含量、脂肪类型、胆固醇含量、胆盐含量进行了一系列优化后形成的含有高饱和脂肪、高胆固醇并添加胆盐的模型饲料，其中，15%脂肪，1.25%胆固醇，0.5%胆盐（ 15% fat, 1.25% cholesterol, and 0.5% sodium cholate）。经过几十年来的使用，效果稳定，
(2)由于是纯化型饲料，原料中不含影响实验结果的因素。
(3)与日粮型Paigen饲料相比，纯化型饲料的唯一缺点是价格偏高，但由于小鼠每天摄入饲料量较小（只有5g左右），因此，实际需要的成本都能在可接受的范围。
因此，纯化型Paigen模型饲料成为C47小鼠中经典的复制动脉粥样硬化模型的理想饲料。正是这样的原因，我们鼓励研究人员优先选用纯化型。事实上，SCI论文中绝大多数都采用这种类型。
2.纯化型Paigen饲料的缺点
纯化型Paigen饲料存在两方面的问题：一是由于对实验动物营养需求的认识，该模型饲料诞生时营养素配比存在不合理，需要优化；二是，当时是针对接近成年C57小鼠进行配比和研究，如果在成年动物开始喂养有其是在老龄小鼠中复制模型时需要优化。点击浏览详细介绍：纯化型Paigen高脂高胆固醇模型饲料及造模注意事项。
因此，南通特洛菲饲料科技有限公司提供了3种不同代码的纯化型Paigen饲料供研究者选用：不优化（TP28900），优化到未成年期喂养的动物（TP28620），特别针对成年期动物进行了设计（TP28640）。
此外，高蛋氨酸摄入可以引起高同型半胱氨酸血症，从而对动脉粥样硬化发挥作用，因此，南通特洛菲饲料科技有限公司还提供在Paigen饲料中添加蛋氨酸的模型饲料（TP28800和TP28810），以及维生素B12和叶酸缺乏的模型饲料（TP25580和TP25581）。
纯化型Paigen模型饲料
纯化型Paigen饲料
TP28600
与Paigen模型饲料设计相同，15%脂肪，1.25%胆固醇，0.5%胆盐，用于未成年开始喂养。点击：展开↓
TP28620
与Paigen模型饲料相似，15%脂肪，1.25%胆固醇，0.5%胆盐，但优化了微量营养素。用于未成年期开始喂养。点击：展开↓
TP28640
与Paigen模型饲料设计相似，15%脂肪，1.25%胆固醇，0.5%胆盐，但针对成年或将近动物而特别设计。点击：展开↓
纯化型Paigen饲料添加蛋氨酸
TP28800
与Paigen模型饲料设计相同，15%脂肪，1.25%胆固醇，0.5%胆盐，并添加蛋氨酸。用于未成年开始喂养。点击：展开↓
TP28810
与Paigen模型饲料设计相同，15%脂肪，1.25%胆固醇，0.5%胆盐，并添加蛋氨酸。用于成年开始喂养。点击：展开↓
纯化型Paigen饲料+B12和叶酸缺乏
TP25580
与Paigen模型饲料设计相同，15%脂肪，1.25%胆固醇，0.5%胆盐，但B12和叶酸缺乏。用于未成年开始喂养。点击：展开↓
TP25581
与Paigen模型饲料设计相同，15%脂肪，1.25%胆固醇，0.5%胆盐，其中，维生素B12和叶酸缺乏。用于成年开始喂养。点击：展开↓
二、C57小鼠动脉粥样硬化模型纯化型Paigen饲料购买和使用注意事项
(1)复制模型的对照饲料应当采用配套的纯化型模型饲料，而不应当使用一般喂养的日粮型饲料。
(2)模型喂养效果的关键还取决于动物的年龄、性别。因此，在实验设计方面务必注意。
(3)模型饲料中胆盐可能对某些生化指标或者分子生物学指标有影响。
(4)除了动脉粥样硬化，还可能伴有胆结石或脂肪肝。
对于这些方面如果有疑问，请与南通特洛菲饲料科技有限公司技术部联系。
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