动脉粥样硬化模型
- 动脉粥样硬化模型饲料和方法综述
- 大鼠、小鼠造模饲料
- 正常大鼠、小鼠模型饲料
- ◄−−----C57小鼠模型饲料
- 基因工程小鼠模型饲料
- 基因敲除或转基因鼠日常喂养饲料
- ApoE基因敲除(ApoE-/-)小鼠
- LDL受体基因敲除(LDLR-KO)小鼠
- 兔模型饲料
- 地鼠模型饲料
- 豚鼠模型饲料
- 鸽子模型饲料
- 鹌鹑模型饲料
- 鸡模型饲料
- 猪或微型猪模型饲料
- 非人灵长类（猴，等）模型饲料
C57BL/6小鼠
动脉粥样硬化模型造模和造模方法
Model Diet of Atherosclerosis for
C57BL6 Mice
C57BL/6小鼠是所有正常小鼠中对动脉粥样硬化相对敏感的品系，从而被广泛用于高脂血症和动脉粥样硬化研究和模型造模。在我国，一般所说的C57也都是指的这个品系，不过，建议你在购买C57时应当确认是否C57BL6。
一、C57小鼠对动脉粥样硬化模型造模的优势和特点
【C57小鼠的优势】
（1）国内有多个单位提供，购买容易。
（2）喂养的模型饲料成本低。每只小鼠每天饲料消耗量只有几克。
（3）应用C57小鼠复制动脉粥样硬化模型或者从事动脉粥样硬化的研究，其优势是这个品系的小鼠具有代谢综合症的基因倾向，不仅相对容易地形成动脉粥样硬化，而且研究结果容易与其他相关研究文献的研究结果结合起来分析和讨论。
【C57小鼠的缺点】
（1）C57小鼠与其他小鼠相似：血浆胆固醇在不同脂蛋白中的分布不同于人；
（2）C57小鼠的高脂血症属于高胆固醇血症，一般不能形成高甘油三酯血症。
（3）所形成的动脉粥样硬化只能发展到脂质条纹期，不能形成斑块。
（4）动脉粥样硬化发生部位在主动脉起始部位，与人类不同。损伤部位小，仅有800-1000平方微米左右。
如果这些方面不能满足你的研究需要，应当考虑选择其他动物。
二、C57小鼠动脉粥样硬化模型复制的饲料
由于Paigen等研究者已经对多种品系大鼠进行了动脉粥样硬化模型饲料进行了针对性的研究，所设计的模型饲料已经成为经典和通行的动脉粥样硬化模型饲料，因此，C57是过去和当前最常用的动脉粥样硬化模型饲料。
由于原料不同，Paigen饲料包括日粮型和纯化型两类模型饲料。
此外，目前的研究认为，同型半胱氨酸血症（HHCY）在动脉粥样硬化形成过程中发挥作用。因此，C57小鼠可以用Paigen饲料基础上添加蛋氨酸的模型饲料，这种饲料属于纯化型饲料（为了准确控制蛋氨酸含量）。
总之，C57小鼠动脉粥样硬化研究或者用于模型造模的饲料，包括两种模型饲料：
点击上述超链接，详细了解模型饲料和选择方法。在上述模型饲料，应当优先选择纯化型。
三、C57小鼠的选择和动脉粥样硬化造模其他注意事项
(1)在研究设计中，应当特别注意C57的性别、年龄，这在动脉粥样硬化造模中非常关键。
(2)由于不同窝的老鼠之间会不和谐，往往因此造成彼此受伤，这可能会引起体内的炎症反应，从而影响研究结果，因此，应当在断奶时不同窝混合喂养，否则，应该单笼喂养。具有举足轻重的斑块部位：在主动脉根部和近段形成小的脂质条纹（不能发展到斑块阶段）。
有不清楚之处以及其他方面的注意事项，请与南通特洛菲饲料科技有限公司技术部联系。
References：
Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, et al. Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway. Arteriosclerosis, thrombosis, and vascular biology. 2014.
Wanschel AC, Caceres VM, Moretti AI, Bruni-Cardoso A, de Carvalho HF, de Souza HP, et al. Cardioprotective mechanism of S-nitroso-N-acetylcysteine via S-nitrosated betadrenoceptor-2 in the LDLr-/- mice. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. 2014;36:58-66.
Steiner T, Francescut L, Byrne S, Hughes T, Jayanthi A, Guschina I, et al. Protective role for properdin in progression of experimental murine atherosclerosis. PloS one. 2014;9(3):e92404.
Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, et al. Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation. 2014;129(5):598-606.
Plat J, Theuwissen E, Husche C, Lutjohann D, Gijbels MJ, Jeurissen M, et al. Oxidised plant sterols as well as oxycholesterol increase the proportion of severe atherosclerotic lesions in female LDL receptor+/ - mice. The British journal of nutrition. 2014;111(1):64-70.
Neuhofer A, Wernly B, Leitner L, Sarabi A, Sommer NG, Staffler G, et al. An accelerated mouse model for atherosclerosis and adipose tissue inflammation. Cardiovascular diabetology. 2014;13:23.
Meydani M, Kwan P, Band M, Knight A, Guo W, Goutis J, et al. Long-term vitamin E supplementation reduces atherosclerosis and mortality in Ldlr-/- mice, but not when fed Western style diet. Atherosclerosis. 2014;233(1):196-205.
Hasan ST, Zingg JM, Kwan P, Noble T, Smith D, Meydani M. Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. Atherosclerosis. 2014;232(1):40-51.
Funke A, Schreurs M, Aparicio-Vergara M, Sheedfar F, Gruben N, Kloosterhuis NJ, et al. Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice. Atherosclerosis. 2014;232(2):390-6.
de Haan W, Bhattacharjee A, Ruddle P, Kang MH, Hayden MR. ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity. Journal of lipid research. 2014;55(3):516-23.
Dai Y, Palade P, Wang X, Mercanti F, Ding Z, Dai D, et al. High fat diet causes renal fibrosis in LDLr-null mice through MAPK-NF-kappaB pathway mediated by Ox-LDL. Journal of cardiovascular pharmacology. 2014;63(2):158-66.
Cochain C, Chaudhari SM, Koch M, Wiendl H, Eckstein HH, Zernecke A. Programmed Cell Death-1 Deficiency Exacerbates T Cell Activation and Atherogenesis despite Expansion of Regulatory T Cells in Atherosclerosis-Prone Mice. PloS one. 2014;9(4):e93280.
Busch M, Westhofen TC, Koch M, Lutz MB, Zernecke A. Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. PloS one. 2014;9(2):e88452.
Al Rajabi A, Castro GS, da Silva RP, Nelson RC, Thiesen A, Vannucchi H, et al. Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet. The Journal of nutrition. 2014;144(3):252-7.
Zhao J, Zhu H, Wang S, Ma X, Liu X, Wang C, et al. Naoxintong protects against atherosclerosis through lipid-lowering and inhibiting maturation of dendritic cells in LDL receptor knockout mice fed a high-fat diet. Current pharmaceutical design. 2013;19(33):5891-6.
Zhang BC, Li XK, Che WL, Li WM, Hou L, Wei YD, et al. [Peroxisome proliferator-activated receptor alpha/gamma agonist tesaglitazar stabilizes atherosclerotic plaque in diabetic low density lipoprotein receptor knockout mice]. Zhonghua xin xue guan bing za zhi. 2013;41(2):143-9.
Yoshimura Y, Nishii S, Zaima N, Moriyama T, Kawamura Y. Ellagic acid improves hepatic steatosis and serum lipid composition through reduction of serum resistin levels and transcriptional activation of hepatic ppara in obese, diabetic KK-A(y) mice. Biochemical and biophysical research communications. 2013;434(3):486-91.
Xia M, Chen D, Endresz V, Faludi I, Szabo A, Gonczol E, et al. Immunization of Chlamydia pneumoniae (Cpn)-infected Apob(tm2Sgy)Ldlr(tm1Her)/J mice with a combined peptide of Cpn significantly reduces atherosclerotic Wen S, Jadhav KS, Williamson DL, Rideout TC. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. Journal of lipids. 2013;2013:908048.
Wang S, Miller B, Matthan NR, Goktas Z, Wu D, Reed DB, et al. Aortic cholesterol accumulation correlates with systemic inflammation but not hepatic and gonadal adipose tissue inflammation in low-density lipoprotein receptor null mice. Nutrition research. 2013;33(12):1072-82.
van Leeuwen M, Kemna MJ, de Winther MP, Boon L, Duijvestijn AM, Henatsch D, et al. Passive immunization with hypochlorite-oxLDL specific antibodies reduces plaque volume in LDL receptor-deficient mice. PloS one. 2013;8(7):e68039.
Subramanian S, Turner MS, Ding Y, Goodspeed L, Wang S, Buckner JH, et al. Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice. Journal of lipid research. 2013;54(10):2831-41.
Strack AM, Carballo-Jane E, Wang SP, Xue J, Ping X, McNamara LA, et al. Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis. Journal of lipid research. 2013;54(1):177-88.
Sinningen K, Rauner M, Goettsch C, Al-Fakhri N, Schoppet M, Hofbauer LC. Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro. Biochemical and biophysical research communications. 2013;437(2):314-8.
Saraswathi V, Ramnanan CJ, Wilks AW, Desouza CV, Eller AA, Murali G, et al. Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. Metabolism: clinical and experimental. 2013;62(11):1673-85.
更多References，点击：展开↓
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Makinen PI, et al. The absence of macrophage Nrf2 promotes early atherogenesis. Cardiovascular research. 2013;98(1):107-15.
Radonjic M, Wielinga PY, Wopereis S, Kelder T, Goelela VS, Verschuren L, et al. Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice. PloS one. 2013;8(2):e56122.
Muthuramu I, Jacobs F, Singh N, Gordts SC, De Geest B. Selective homocysteine lowering gene transfer improves infarct healing, attenuates remodelling, and enhances diastolic function after myocardial infarction in mice. PloS one. 2013;8(5):e63710.
Mundkur LA, Varma M, Shivanandan H, Krishna D, Kumar K, Lu X, et al. Activation of inflammatory cells and cytokines by peptide epitopes in vitro: a simple in-vitro screening assay for prioritizing them for in-vivo studies. Inflammation research : official journal of the European Histamine Research Society [et al]. 2013;62(5):471-81.
Manthey HD, Cochain C, Barnsteiner S, Karshovska E, Pelisek J, Koch M, et al. CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Thrombosis and haemostasis. 2013;110(6):1267-77.
Luo N, Chung BH, Wang X, Klein RL, Tang CK, Garvey WT, et al. Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages. Atherosclerosis. 2013;228(1):124-35.
Lou Y, Liu S, Zhang C, Zhang G, Li J, Ni M, et al. Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein. Journal of immunology. 2013;191(9):4849-57.
Lorbek G, Perse M, Horvat S, Bjorkhem I, Rozman D. Sex differences in the hepatic cholesterol sensing mechanisms in mice. Molecules. 2013;18(9):11067-85.
Liu J, Xu A, Lam KS, Wong NS, Chen J, Shepherd PR, et al. Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. Oncotarget. 2013;4(10):1804-18.
LLee RG, Fu W, Graham MJ, Mullick AE, Sipe D, Gattis D, et al. Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein. Journal of lipid research. 2013;54(3):602-14.
Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, et al. Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models. American journal of physiology Endocrinology and metabolism. 2013;305(5):E573-84.
Kinnunen K, Heinonen SE, Kalesnykas G, Laidinen S, Uusitalo-Jarvinen H, Uusitalo H, et al. LDLR-/-ApoB100/100 mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina. Molecular vision. 2013;19:1723-33.
Hendrikx T, Bieghs V, Walenbergh SM, van Gorp PJ, Verheyen F, Jeurissen ML, et al. Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice. PloS one. 2013;8(12):e78792.
Han L, Tang MX, Ti Y, Wang ZH, Wang J, Ding WY, et al. Overexpressing STAMP2 improves insulin resistance in diabetic ApoE(-)/(-)/LDLR(-)/(-) mice via macrophage polarization shift in adipose tissues. PloS one. 2013;8(11):e78903.
Gupte AA, Minze LJ, Reyes M, Ren Y, Wang X, Brunner G, et al. High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. Endocrinology. 2013;154(8):2650-62.
Guo W, Wong S, Bhasin S. AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis. PloS one. 2013;8(8):e71017.
Foley EM, Gordts PL, Stanford KI, Gonzales JC, Lawrence R, Stoddard N, et al. Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arteriosclerosis, thrombosis, and vascular biology. 2013;33(9):2065-74.
Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, et al. Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. Journal of applied physiology. 2013;115(11):1694-704.
Ding Z, Mizeracki AM, Hu C, Mehta JL. LOX-1 deletion and macrophage trafficking in atherosclerosis. Biochemical and biophysical research communications. 2013;440(2):210-4.
Ding Z, Liu S, Wang X, Khaidakov M, Dai Y, Mehta JL. Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis. Scientific reports. 2013;3:1077.
Di Mascolo D, C JL, Aryal S, Ramirez MR, Wang J, Candeloro P, et al. Rosiglitazone-loaded nanospheres for modulating macrophage-specific inflammation in obesity. Journal of controlled release : official journal of the Controlled Release Society. 2013;170(3):460-8.
Depner CM, Philbrick KA, Jump DB. Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. The Journal of nutrition. 2013;143(3):315-23.
Chakraborty M, Lou C, Huan C, Kuo MS, Park TS, Cao G, et al. Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis. The Journal of clinical investigation. 2013;123(4):1784-97.
Caravaggio JW, asu M, MacLaren R, Thabet M, Raizman JE, Veinot JP, et al. Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2013;22(6):458-64.
CCampbell IC, Weiss D, Suever JD, Virmani R, Veneziani A, Vito RP, et al. Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice. American journal of physiology Heart and circulatory physiology. 2013;304(3):H473-86.
Botelho PB, Mariano Kda R, Rogero MM, de Castro IA. Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. Lipids in health and disease. 2013;12:38.
Bombo RP, Afonso MS, Machado RM, Lavrador MS, Nunes VS, Quintao ER, et al. Dietary phytosterol does not accumulate in the arterial wall and prevents atherosclerosis of LDLr-KO mice. Atherosclerosis. 2013;231(2):442-7.
Bieghs V, Hendrikx T, van Gorp PJ, Verheyen F, Guichot YD, Walenbergh SM, et al. The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology. 2013;144(1):167-78 e1.
Assini JM, Mulvihill EE, Sutherland BG, Telford DE, Sawyez CG, Felder SL, et al. Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr(-)/(-) mice. Journal of lipid research. 2013;54(3):711-24.
Ali H, Emoto N, Yagi K, Vignon-Zellweger N, Nakayama K, Hatakeyama K, et al. Localization and Characterization of a Novel Secreted Protein, SCUBE2, in the Development and Progression of Atherosclerosis. The Kobe journal of medical sciences. 2013;59(4):E122-31.
Zhang Y, e X, Heemstra LA, Chen WD, Xu J, Smith JL, et al. Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice. Molecular endocrinology. 2012;26(2):272-80.
Zhang L, Ovchinnikova O, Jonsson A, Lundberg AM, Berg M, Hansson GK, et al. The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice. European heart journal. 2012;33(16):2025-34.
Zhang BC, Li WM, Li XK, Zhu MY, Che WL, Xu YW. Tesaglitazar ameliorates non-alcoholic fatty liver disease and atherosclerosis development in diabetic low-density lipoprotein receptor-deficient mice. Experimental and therapeutic medicine. 2012;4(6):987-92.
Zhang BC, Li WM, Guo R, Xu YW. Salidroside decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice. Evidence-based complementary and alternative medicine : eCAM. 2012;2012:607508.
Yang FZ, Zhou J, Li WW, Wang F, Wen PY, Zhou L, et al. [Nuclear factor kappaB and IKB expression and calcium deposition of atherosclerotic plaques in apolipoprotein E and low density lipoprotein receptor knockout mice]. Zhonghua xin xue guan bing za zhi. 2012;40(8):684-9. 63.
Xu J, Wang S, Zhang M, Wang Q, Asfa S, Zou MH. Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors. PloS one. 2012;7(1):e29649.
Wang ZH, Shang YY, Zhang S, Zhong M, Wang XP, Deng JT, et al. Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice. Diabetes. 2012;61(2):463-73.
Umemoto T, Subramanian S, Ding Y, Goodspeed L, Wang S, Han CY, et al. Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation. Journal of lipid research. 2012;53(11):2380-9.
Teodoro BG, Natali AJ, Fernandes SA, Silva LA, Pinho RA, Matta SL, et al. Improvements of atherosclerosis and hepatic oxidative stress are independent of exercise intensity in LDLr(-/-) mice. Journal of atherosclerosis and thrombosis. 2012;19(10):904-11.
Soares EA, Nakagaki WR, Garcia JA, Camilli JA. Effect of hyperlipidemia on femoral biomechanics and morphology in low-density lipoprotein receptor gene knockout mice. Journal of bone and mineral metabolism. 2012;30(4):419-25.
Saraste A, Laitinen I, Weidl E, Wildgruber M, Weber AW, Nekolla SG, et al. Diet intervention reduces uptake of alphavbeta3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2012;19(4):775-84.
Sage AP, Tsiantoulas D, Baker L, Harrison J, Masters L, Murphy D, et al. BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report. Arteriosclerosis, thrombosis, and vascular biology. 2012;32(7):1573-6.
Rensen SS, Bieghs V, Xanthoulea S, Arfianti E, Bakker JA, Shiri-Sverdlov R, et al. Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice. PloS one. 2012;7(12):e52411.
Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, et al. Adverse effects of hyperlipidemia on bone regeneration and strength. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2012;27(2):309-18.
Murali G, Milne GL, Webb CD, Stewart AB, McMillan RP, Lyle BC, et al. Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR(-/-) mice. Journal of lipid research. 2012;53(10):2186-97.
Momi S, Monopoli A, Alberti PF, Falcinelli E, Corazzi T, Conti V, et al. Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis. Cardiovascular research. 2012;94(3):428-38.
Modulo CM, Machado Filho EB, Malki LT, Dias AC, de Souza JC, Oliveira HC, et al. The role of dyslipidemia on ocular surface, lacrimal and meibomian gland structure and function. Current eye research. 2012;37(4):300-8.
Machado RM, Nakandakare ER, Quintao EC, Cazita PM, Koike MK, Nunes VS, et al. Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to trans fatty acids. Atherosclerosis. 2012;224(1):66-74.
Ma Y, Wang W, Zhang J, Lu Y, Wu W, Yan H, et al. Hyperlipidemia and atherosclerotic lesion development in Ldlr-deficient mice on a long-term high-fat diet. PloS one. 2012;7(4):e35835.
Lu X, Xia M, Endresz V, Faludi I, Mundkur L, Gonczol E, et al. Immunization with a combination of 2 peptides derived from the C5a receptor significantly reduces early atherosclerotic lesion in Ldlr(tm1Her) Apob(tm2Sgy) J mice. Arteriosclerosis, thrombosis, and vascular biology. 2012;32(10):2358-71.
LLombardo E, van Roomen CP, van Puijvelde GH, Ottenhoff R, van Eijk M, Aten J, et al. Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism. PloS one. 2012;7(10):e38520.
Lingrel JB, Pilcher-Roberts R, Basford JE, Manoharan P, Neumann J, Konaniah ES, et al. Myeloid-specific Kruppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circulation research. 2012;110(10):1294-302.
Lian J, Quiroga AD, Li L, Lehner R. Ces3/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr(-/-) mice. Circulation research. 2012;111(8):982-90.
Lewis MJ, Malik TH, Fossati-Jimack L, Carassiti D, Cook HT, Haskard DO, et al. Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia. Arthritis and rheumatism. 2012;64(8):2707-18.
Krishna SM, eto SW, Moxon JV, Rush C, Walker PJ, Norman PE, et al. Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. The American journal of pathology. 2012;181(2):706-18.
Kostogrys RB, Franczyk-Zarow M, Maslak E, Gajda M, Mateuszuk L, Jackson CL, et al. Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein E/low-density lipoprotein receptor double knockout mice (apoE/LDLR(-/-)). Atherosclerosis. 2012;223(2):327-31.
Kim EH, Bae JS, Hahm KB, Cha JY. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Biochemical pharmacology. 2012;84(10):1359-65.
Kennedy A, Gruen ML, Gutierrez DA, Surmi BK, Orr JS, Webb CD, et al. Impact of macrophage inflammatory protein-1alpha deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion. PloS one. 2012;7(2):e31508.
Han H, Xin P, Zhao L, Xu J, Xia Y, Yang X, et al. Excess iodine and high-fat diet combination modulates lipid profile, thyroid hormone, and hepatic LDLr expression values in mice. Biological trace element research. 2012;147(1-3):233-9.
Hambruch E, Miyazaki-Anzai S, Hahn U, Matysik S, Boettcher A, Perovic-Ottstadt S, et al. Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. The Journal of pharmacology and experimental therapeutics. 2012;343(3):556-67.
Hager L, Li L, Pun H, Liu L, Hossain MA, Maguire GF, et al. Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. The Journal of biological chemistry. 2012;287(24):20755-68.
Feng Y, Schouteden S, Geenens R, Van Duppen V, Herijgers P, Holvoet P, et al. Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice. PloS one. 2012;7(11):e47286.
Engelbertsen D, To F, Duner P, Kotova O, Soderberg I, Alm R, et al. Increased inflammation in atherosclerotic lesions of diabetic Akita-LDLr(-)/(-) mice compared to nondiabetic LDLr(-)/(-) mice. Experimental diabetes research. 2012;2012:176162.
Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, et al. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2012;32(3):613-22.
Depner CM, Torres-Gonzalez M, Tripathy S, Milne G, Jump DB. Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. The Journal of nutrition. 2012;142(8):1495-503.
Deevska GM, Sunkara M, Morris AJ, Nikolova-Karakashian MN. Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat diet. Bioscience reports. 2012;32(5):479-90.
Curtiss LK, Black AS, Bonnet DJ, Tobias PS. Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists. Journal of lipid research. 2012;53(10):2126-32.
Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, van Bilsen M, et al. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PloS one. 2012;7(1):e30668.
Bieghs V, van Gorp PJ, Walenbergh SM, Gijbels MJ, Verheyen F, Buurman WA, et al. Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice. Hepatology. 2012;56(3):894-903.
Bermejo-Alvarez P, Rosenfeld CS, Roberts RM. Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model. Human reproduction. 2012;27(12):3513-22.
Bai Q, Zhang X, Xu L, Kakiyama G, Heuman D, Sanyal A, et al. Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease. Metabolism: clinical and experimental. 2012;61(6):836-45.
Zhao L, Chen Y, Tang R, Chen Y, Li Q, Gong J, et al. Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis. Journal of gastroenterology and hepatology. 2011;26(5):875-83.
Zhang X, Hurng J, Rateri DL, Daugherty A, Schmid-Schonbein GW, Shin HY. Membrane cholesterol modulates the fluid shear stress response of polymorphonuclear leukocytes via its effects on membrane fluidity. American journal of physiology Cell physiology. 2011;301(2):C451-60.
Yang Y, Seo JM, Nguyen A, Pham TX, Park HJ, Park Y, et al. Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice. The Journal of nutrition. 2011;141(9):1611-7.
Wang L, Yamasaki M, Katsube T, Sun X, Yamasaki Y, Shiwaku K. Antiobesity effect of polyphenolic compounds from molokheiya (Corchorus olitorius L.) leaves in LDL receptor-deficient mice. European journal of nutrition. 2011;50(2):127-33.
Tang EH, Shimizu K, Christen T, Rocha VZ, Shvartz E, Tesmenitsky Y, et al. Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions. Cardiovascular research. 2011;89(1):234-43.
Subramanian S, Goodspeed L, Wang S, Kim J, Zeng L, Ioannou GN, et al. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. Journal of lipid research. 2011;52(9):1626-35.
Silvola JM, Saraste A, Laitinen I, Savisto N, Laine VJ, Heinonen SE, et al. Effects of age, diet, and type 2 diabetes on the development and FDG uptake of atherosclerotic plaques. JACC Cardiovascular imaging. 2011;4(12):1294-301.
Shen L, Matsunami Y, Quan N, Kobayashi K, Matsuura E, Oguma K. In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice. The Israel Medical Association journal : IMAJ. 2011;13(5):278-83.
Shao JS, Sierra OL, Cohen R, Mecham RP, Kovacs A, Wang J, et al. Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2011;31(8):1821-33.
Shah Z, Kampfrath T, Deiuliis JA, Zhong J, Pineda C, Ying Z, et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation. 2011;124(21):2338-49.
Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, et al. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2011;26(6):1197-206.
Paik J, Fierce Y, Mai PO, Phelps SR, McDonald T, Treuting P, et al. Murine norovirus increases atherosclerotic lesion size and macrophages in Ldlr(-/-) mice. Comparative medicine. 2011;61(4):330-8.
Li L, Hossain MA, Sadat S, Hager L, Liu L, Tam L, et al. Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways. The Journal of biological chemistry. 2011;286(20):17809-20.
Kassim SH, Vandenberghe LH, Hovhannisyan R, Wilson JM, Rader DJ. Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques. Physiological genomics. 2011;43(15):911-6.
Karavia EA, Papachristou DJ, Kotsikogianni I, Giopanou I, Kypreos KE. Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice. The FEBS journal. 2011;278(17):3119-29.
Hu MM, Zhang J, Wang WY, Wu WY, Ma YL, Chen WH, et al. The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice. Acta pharmacologica Sinica. 2011;32(10):1253-8.
Heinonen SE, Merentie M, Hedman M, Makinen PI, Loponen E, Kholova I, et al. Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice. Cardiovascular diabetology. 2011;10:59.
Habegger KM, Grant E, Pfluger PT, Perez-Tilve D, Daugherty A, Bruemmer D, et al. Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice. Frontiers in endocrinology. 2011;2:67.
Garcia JA, de Lima CC, Messora LB, Cruz AF, Marques AP, Simao TP, et al. [Anti-inflammatory effect of high-density lipoprotein on the cardiovascular system of hyperlipidemic mice]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2011;30(10):763-9.
Delsing DJ, Leijten FP, Arts K, van Eenennaam H, Garritsen A, Gijbels MJ, et al. Cannabinoid Receptor 2 Deficiency in Haematopoietic cells Aggravates Early Atherosclerosis in LDL Receptor Deficient Mice. The open cardiovascular medicine journal. 2011;5:15-21.
Bie J, Zhao B, Ghosh S. Atherosclerotic lesion progression is attenuated by reconstitution with bone marrow from macrophage-specific cholesteryl ester hydrolase transgenic mice. American journal of physiology Regulatory, integrative and comparative physiology. 2011;301(4):R967-74.
Babaev VR, Runner RP, Fan D, Ding L, Zhang Y, Tao H, et al. Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-gamma-regulated genes. Arteriosclerosis, thrombosis, and vascular biology. 2011;31(6):1283-90.
Awan Z, Denis M, Bailey D, Giaid A, Prat A, Goltzman D, et al. The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis. 2011;219(2):455-62.
Yamamoto Y, Yamashita T, Kitagawa F, Sakamoto K, Giddings JC, Yamamoto J. The effect of the long term aspirin administration on the progress of atherosclerosis in apoE-/- LDLR-/- double knockout mouse. Thrombosis research. 2010;125(3):246-52.
Vinaixa M, Rodriguez MA, Rull A, Beltran R, Blade C, Brezmes J, et al. Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease. Journal of proteome research. 2010;9(5):2527-38.
Tandy S, Chung RW, Kamili A, Wat E, Weir JM, Meikle PJ, et al. Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet. Atherosclerosis. 2010;213(1):142-7.
Rull A, Beltran-Debon R, Aragones G, Rodriguez-Sanabria F, Alonso-Villaverde C, Camps J, et al. Expression of cytokine genes in the aorta is altered by the deficiency in MCP-1: effect of a high-fat, high-cholesterol diet. Cytokine. 2010;50(2):121-8.
Nookaew I, Gabrielsson BG, Holmang A, Sandberg AS, Nielsen J. Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice. PloS one. 2010;5(8):e12361.
Ngai YF, Quong WL, Glier MB, Glavas MM, Babich SL, Innis SM, et al. Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis. Endocrinology. 2010;151(11):5226-36.
Malik TH, Cortini A, Carassiti D, Boyle JJ, Haskard DO, Botto M. The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2010;122(19):1948-56.
Mak S, Sun H, Acevedo F, Shimmin LC, Zhao L, Teng BB, et al. Differential expression of genes in the calcium-signaling pathway underlies lesion development in the LDb mouse model of atherosclerosis. Atherosclerosis. 2010;213(1):40-51.
Litvinov D, Selvarajan K, Garelnabi M, Brophy L, Parthasarathy S. Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. Atherosclerosis. 2010;209(2):449-54.
Kozak LP, Newman S, Chao PM, Mendoza T, Koza RA. The early nutritional environment of mice determines the capacity for adipose tissue expansion by modulating genes of caveolae structure. PloS one. 2010;5(6):e11015.
Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, et al. Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10. Cardiovascular research. 2010;85(1):224-31.
Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, et al. Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology. 2010;52(6):2001-11.
Golledge J, Cullen B, Moran C, Rush C. Efficacy of simvastatin in reducing aortic dilatation in mouse models of abdominal aortic aneurysm. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. 2010;24(5-6):373-8.
Chang X, Yan H, Fei J, Jiang M, Zhu H, Lu D, et al. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. Journal of lipid research. 2010;51(9):2504-15.
Bonfleur ML, Vanzela EC, Ribeiro RA, de Gabriel Dorighello G, de Franca Carvalho CP, Collares-Buzato CB, et al. Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity. Biochimica et biophysica acta. 2010;1801(2):183-90.
Bielicki JK, Zhang H, Cortez Y, Zheng Y, Narayanaswami V, Patel A, et al. A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice. Journal of lipid research. 2010;51(6):1496-503.
Bie J, Zhao B, Song J, Ghosh S. Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr-/- mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: role of macrophage inflammation and infiltration into adipose tissue. The Journal of biological chemistry. 2010;285(18):13630-7.
Zou Y, Du H, Yin M, Zhang L, Mao L, Xiao N, et al. Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice. Molecular and cellular biochemistry. 2009;323(1-2):195-205.
Zhu L, Stalker TJ, Fong KP, Jiang H, Tran A, Crichton I, et al. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(7):1039-45.
Zhao Y, Su B, Jacobs RL, Kennedy B, Francis GA, Waddington E, et al. Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(9):1349-55.
Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH. Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse. Atherosclerosis. 2009;204(1):147-55.
VanderLaan PA, Reardon CA, Thisted RA, Getz GS. VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice. Journal of lipid research. 2009;50(3):376-85.
van Leeuwen M, Damoiseaux J, Duijvestijn A, Heeringa P, Gijbels M, de Winther M, et al. The IgM response to modified LDL in experimental atherosclerosis: hypochlorite-modified LDL IgM antibodies versus classical natural T15 IgM antibodies. Annals of the New York Academy of Sciences. 2009;1173:274-9.
Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, et al. Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes. 2009;58(8):1739-48.
Sun L, Ishida T, Yasuda T, Kojima Y, Honjo T, Yamamoto Y, et al. RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice. Cardiovascular research. 2009;82(2):371-81.
Soares SR, Carvalho-Oliveira R, Ramos-Sanchez E, Catanozi S, da Silva LF, Mauad T, et al. Air pollution and antibodies against modified lipoproteins are associated with atherosclerosis and vascular remodeling in hyperlipemic mice. Atherosclerosis. 2009;207(2):368-73.
Saraswathi V, Morrow JD, Hasty AH. Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/- mice. The Journal of nutrition. 2009;139(12):2380-6.
Rull A, Rodriguez F, Aragones G, Marsillach J, Beltran R, Alonso-Villaverde C, et al. Hepatic monocyte chemoattractant protein-1 is upregulated by dietary cholesterol and contributes to liver steatosis. Cytokine. 2009;48(3):273-9.
Nakaya H, Summers BD, Nicholson AC, Gotto AM, Jr., Hajjar DP, Han J. Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone. The American journal of pathology. 2009;174(6):2007-14.
Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes. 2009;58(10):2198-210.
Matthijsen RA, de Winther MP, Kuipers D, van der Made I, Weber C, Herias MV, et al. Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2009;119(16):2188-95.
Luo Y, Warren L, Xia D, Jensen H, Sand T, Petras S, et al. Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice. Journal of lipid research. 2009;50(8):1581-8.
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO. Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2009;120(5):417-26.
Leung VW, Yun S, Botto M, Mason JC, Malik TH, Song W, et al. Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice. The American journal of pathology. 2009;175(4):1757-67.
Kong B, Luyendyk JP, Tawfik O, Guo GL. Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. The Journal of pharmacology and experimental therapeutics. 2009;328(1):116-22.
Kim GH, Park K, Yeom SY, Lee KJ, Kim G, Ko J, et al. Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages. Molecular endocrinology. 2009;23(7):966-74.
Kellokoski E, Kummu O, Serpi R, Lehenkari P, Ukkola O, Kesaniemi YA, et al. Ghrelin vaccination decreases plasma MCP-1 level in LDLR(-/-)-mice. Peptides. 2009;30(12):2292-300.
Guo W, Wong S, Pudney J, Jasuja R, Hua N, Jiang L, et al. Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(12):2028-32.
Guo H, Shi Y, Liu L, Sun A, Xu F, Chi J. Rosuvastatin inhibits MMP-2 expression and limits the progression of atherosclerosis in LDLR-deficient mice. Archives of medical research. 2009;40(5):345-51.
Franco C, Britto K, Wong E, Hou G, Zhu SN, Chen M, et al. Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis. Circulation research. 2009;105(11):1141-8.
de Nooijer R, Bot I, von der Thusen JH, Leeuwenburgh MA, Overkleeft HS, Kraaijeveld AO, et al. Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(2):188-94.
Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, et al. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circulation research. 2009;104(6):e42-54.
Coenen KR, Gruen ML, Lee-Young RS, Puglisi MJ, Wasserman DH, Hasty AH. Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia. 2009;52(2):318-28.
Bhasin KK, van Nas A, Martin LJ, Davis RC, Devaskar SU, Lusis AJ. Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes. 2009;58(3):559-66.
Ayada K, Yokota K, Hirai K, Fujimoto K, Kobayashi K, Ogawa H, et al. Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis. Lupus. 2009;18(13):1154-68. Zhou X, He W, Huang Z, Gotto AM, Jr., Hajjar DP, Han J. Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism. The Journal of biological chemistry. 2008;283(4):2129-38.
Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, et al. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. The Journal of clinical investigation. 2008;118(6):2281-90.
Yun S, Leung VW, Botto M, Boyle JJ, Haskard DO. Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59. Arteriosclerosis, thrombosis, and vascular biology. 2008;28(10):1714-6.
Xu B, Wang C, Yang J, Mao G, Zhang C, Liu D, et al. Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA. Biological & pharmaceutical bulletin. 2008;31(6):1182-91.
Wouters K, van Gorp PJ, Bieghs V, Gijbels MJ, Duimel H, Lutjohann D, et al. Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology. 2008;48(2):474-86.
Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, et al. Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation. 2008;117(10):1302-9.
vvan Leeuwen M, Gijbels MJ, Duijvestijn A, Smook M, van de Gaar MJ, Heeringa P, et al. Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR-/- mice. Arteriosclerosis, thrombosis, and vascular biology. 2008;28(1):84-9.
Valenta DT, Bulgrien JJ, Bonnet DJ, Curtiss LK. Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiency. Journal of lipid research. 2008;49(1):24-32.
Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, et al. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. Journal of neurochemistry. 2008;106(1):475-85.
Ketonen J, Mervaala E. Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low-density lipoprotein receptor-deficient mice on high-fat diet. Heart and vessels. 2008;23(6):420-9.
Jacobs F, Van Craeyveld E, Feng Y, Snoeys J, De Geest B. Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia. Atherosclerosis. 2008;201(2):289-97.
Huang Z, Zhou X, Nicholson AC, otto AM, Jr., Hajjar DP, Han J. Activation of peroxisome proliferator-activated receptor-alpha in mice induces expression of the hepatic low-density lipoprotein receptor. British journal of pharmacology. 2008;155(4):596-605.
Hime NJ, Black AS, Bulgrien JJ, Curtiss LK. Leukocyte-derived hepatic lipase increases HDL and decreases en face aortic atherosclerosis in LDLr-/- mice expressing CETP. Journal of lipid research. 2008;49(10):2113-23.
Ellis A, Cheng ZJ, Li Y, Jiang YF, Yang J, Pannirselvam M, et al. Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature. European journal of pharmacology. 2008;601(1-3):111-7.
Braun N, Wade NS, Wakeland EK, Major AS. Accelerated atherosclerosis is independent of feeding high fat diet in systemic lupus erythematosus-susceptible LDLr(-/-) mice. Lupus. 2008;17(12):1070-8.
Ait-Oufella H, Pouresmail V, Simon T, Blanc-Brude O, Kinugawa K, Merval R, et al. Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2008;28(8):1429-31.
Zhao B, Song J, Chow WN, St Clair RW, Rudel LL, Ghosh S. Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice. The Journal of clinical investigation. 2007;117(10):2983-92.
Xu Y, Arai H, Murayama T, Kita T, Yokode M. Hypercholesterolemia contributes to the development of atherosclerosis and vascular remodeling by recruiting bone marrow-derived cells in cuff-induced vascular injury. Biochemical and biophysical research communications. 2007;363(3):782-7.
Schiopu A, Frendeus B, Jansson B, Soderberg I, Ljungcrantz I, Araya Z, et al. Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) mice. Journal of the American College of Cardiology. 2007;50(24):2313-8.
Saraswathi V, Gao L, Morrow JD, Chait A, Niswender KD, Hasty AH. Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. The Journal of nutrition. 2007;137(7):1776-82.
Recinos A, 3rd, LeJeune WS, Sun H, Lee CY, Tieu BC, Lu M, et al. Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice. Atherosclerosis. 2007;194(1):125-33.
Qian K, Agrawal N, Dichek HL. Reduced atherosclerosis in chow-fed mice expressing high levels of a catalytically inactive human hepatic lipase. Atherosclerosis. 2007;195(1):66-74.
Pennings M, Hildebrand RB, Ye D, Kunne C, Van Berkel TJ, Groen AK, et al. Bone marrow-derived multidrug resistance protein ABCB4 protects against atherosclerotic lesion development in LDL receptor knockout mice. Cardiovascular research. 2007;76(1):175-83.
Pellizzon MA, Billheimer JT, Bloedon LT, Szapary PO, Rader DJ. Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models. Journal of the American College of Nutrition. 2007;26(1):66-75.
Nuotio-Antar AM, Hachey DL, Hasty AH. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. American journal of physiology Endocrinology and metabolism. 2007;293(6):E1517-28.
Heinonen SE, Leppanen P, Kholova I, Lumivuori H, Hakkinen SK, Bosch F, et al. Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia. Circulation research. 2007;101(10):1058-67.
Hasty AH, Gruen ML, Terry ES, Surmi BK, Atkinson RD, Gao L, et al. Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model. The Journal of nutritional biochemistry. 2007;18(2):127-33.
Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, et al. Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(28):11766-71.
Cyrus T, Yao Y, Ding T, Dogne JM, Pratico D. Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice. Blood. 2007;109(8):3291-6.
Coenen KR, Hasty AH. Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice. American journal of physiology Endocrinology and metabolism. 2007;293(2):E492-9.
Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, et al. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2007;116(12):1404-12.
WWu L, Vikramadithyan R, Yu S, Pau C, Hu Y, Goldberg IJ, et al. Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: effects on plasma insulin, lipoproteins, and atherosclerosis. Journal of lipid research. 2006;47(10):2215-22.
Valenta DT, Ogier N, Bradshaw G, Black AS, Bonnet DJ, Lagrost L, et al. Atheroprotective potential of macrophage-derived phospholipid transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apolipoprotein AI overexpression. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(7):1572-8.
Valenta DT, Bulgrien JJ, Banka CL, Curtiss LK. Overexpression of human ApoAI transgene provides long-term atheroprotection in LDL receptor-deficient mice. Atherosclerosis. 2006;189(2):255-63.
Towler DA, Shao JS, Cheng SL, Pingsterhaus JM, Loewy AP. Osteogenic regulation of vascular calcification. Annals of the New York Academy of Sciences. 2006;1068:327-33.
Tian J, Pei H, Sanders JM, Angle JF, Sarembock IJ, Matsumoto AH, et al. Hyperlipidemia is a major determinant of neointimal formation in LDL receptor-deficient mice. Biochemical and biophysical research communications. 2006;345(3):1004-9.
Srivastava RA, Jahagirdar R, Azhar S, Sharma S, Bisgaier CL. Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice. Molecular and cellular biochemistry. 2006;285(1-2):35-50.
Raikwar NS, Cho WK, Bowen RF, Deeg MA. Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism. American journal of physiology Endocrinology and metabolism. 2006;290(3):E463-70.
Potteaux S, Combadiere C, Esposito B, Lecureuil C, Ait-Oufella H, Merval R, et al. Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor knockout mice. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(8):1858-63.
Out R, Hoekstra M, Hildebrand RB, ruit JK, Meurs I, Li Z, et al. Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(10):2295-300.
Ijiri Y, Naemura A, Yamashita T, Meguro S, Watanabe H, Tokimitsu I, et al. Dietary diacylglycerol extenuates arterial thrombosis in apoE and LDLR deficient mice. Thrombosis research. 2006;117(4):411-7.
Huang C, Zhang Y, Gong Z, Sheng X, Li Z, Zhang W, et al. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochemical and biophysical research communications. 2006;348(2):571-8.
He L, Game BA, Nareika A, Garvey WT, Huang Y. Administration of pioglitazone in low-density lipoprotein receptor-deficient mice inhibits lesion progression and matrix metalloproteinase expression in advanced atherosclerotic plaques. Journal of cardiovascular pharmacology. 2006;48(5):212-22.
Drolet MC, Roussel E, Deshaies Y, Couet J, Arsenault M. A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice. Journal of the American College of Cardiology. 2006;47(4):850-5.
Cyrus T, Yao Y, Tung LX, Pratico D. Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin. Atherosclerosis. 2006;184(1):8-14.
Basso F, Amar MJ, Wagner EM, Vaisman B, Paigen B, Santamarina-Fojo S, et al. Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet. Biochemical and biophysical research communications. 2006;351(2):398-404.
Baldan A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, et al. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(10):2301-7.
Asakura L, Cazita PM, Harada LM, Nunes VS, Berti JA, Salerno AG, et al. Soy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice. Lipids. 2006;41(7):655-62.
Thorbjornsdottir P, Kolka R, Gunnarsson E, Bambir SH, Thorgeirsson G, Kotwal GJ, et al. Vaccinia virus complement control protein diminishes formation of atherosclerotic lesions: complement is centrally involved in atherosclerotic disease. Annals of the New York Academy of Sciences. 2005;1056:1-15.
Steioff K, Rutten H, Busch AE, Plettenburg O, Ivashchenko Y, Lohn M. Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice. European journal of pharmacology. 2005;512(2-3):247-9.
Seidelmann SB, De Luca C, Leibel RL, Breslow JL, Tall AR, Welch CL. Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arteriosclerosis, thrombosis, and vascular biology. 2005;25(1):204-10.
Espirito Santo SM, Rensen PC, Goudriaan JR, Bensadoun A, Bovenschen N, Voshol PJ, et al. Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice. Journal of lipid research. 2005;46(6):1097-102.
Ding T, Yao Y, Pratico D. Increase in peripheral oxidative stress during hypercholesterolemia is not reflected in the central nervous system: evidence from two mouse models. Neurochemistry international. 2005;46(6):435-9.
Crooke RM, Graham MJ, Lemonidis KM, Whipple CP, Koo S, Perera RJ. An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis. Journal of lipid research. 2005;46(5):872-84.
Yoshimatsu M, Terasaki Y, Sakashita N, Kiyota E, Sato H, van der Laan LJ, et al. Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. International journal of experimental pathology. 2004;85(6):335-43.
Wilund KR, Yu L, Xu F, Hobbs HH, Cohen JC. High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/- mice. Journal of lipid research. 2004;45(8):1429-36.
Tintut Y, Morony S, Demer LL. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arteriosclerosis, thrombosis, and vascular biology. 2004;24(2):e6-10.
Recinos A, 3rd, Carr BK, Bartos DB, Boldogh I, Carmical JR, Belalcazar LM, et al. Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway. Physiological genomics. 2004;19(1):131-42.
Potteaux S, Esposito B, van Oostrom O, Brun V, Ardouin P, Groux H, et al. Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice. Arteriosclerosis, thrombosis, and vascular biology. 2004;24(8):1474-8.
Niwa T, Wada H, Ohashi H, Iwamoto N, Ohta H, Kirii H, et al. Interferon-gamma produced by bone marrow-derived cells attenuates atherosclerotic lesion formation in LDLR-deficient mice. Journal of atherosclerosis and thrombosis. 2004;11(2):79-87.
Lewis KE, Kirk EA, McDonald TO, Wang S, Wight TN, O'Brien KD, et al. Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice. Circulation. 2004;110(5):540-5.
Kim J, Nam KH, Kim SO, Choi JH, Kim HC, Yang SD, et al. KR-31378 ameliorates atherosclerosis by blocking monocyte recruitment in hypercholestrolemic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004;18(6):714-6.
Kanters E, Gijbels MJ, van der Made I, Vergouwe MN, Heeringa P, Kraal G, et al. Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype. Blood. 2004;103(3):934-40.
Jeong S, Kim M, Han M, Lee H, Ahn J, Kim M, et al. Fenofibrate prevents obesity and hypertriglyceridemia in low-density lipoprotein receptor-null mice. Metabolism: clinical and experimental. 2004;53(5):607-13.
Fukao H, Ijiri Y, Miura M, Hashimoto M, Yamashita T, Fukunaga C, et al. Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2004;15(6):441-6.
Dichek HL, Qian K, Agrawal N. Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2004;24(9):1696-702.
Yoon M, Jeong S, Lee H, Han M, Kang JH, Kim EY, et al. Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice. Biochemical and biophysical research communications. 2003;302(1):29-34.
Wu JH, Peppel K, Nelson CD, Lin FT, Kohout TA, Miller WE, et al. The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. The Journal of biological chemistry. 2003;278(45):44238-45.
Weng S, Zemany L, Standley KN, Novack DV, La Regina M, Bernal-Mizrachi C, et al. Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(11):6730-5.
Schreyer SA, Lystig TC, Vick CM, LeBoeuf RC. Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity. Atherosclerosis. 2003;171(1):49-55.
Mallat Z, Gojova A, Sauzeau V, Brun V, Silvestre JS, Esposito B, et al. Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice. Circulation research. 2003;93(9):884-8.
Lieu HD, Withycombe SK, Walker Q, Rong JX, Walzem RL, Wong JS, et al. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation. 2003;107(9):1315-21.
Dutta R, Singh U, Li TB, Fornage M, Teng BB. Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes. Atherosclerosis. 2003;169(1):51-62. Deeg MA. Dietary cholate is required for antiatherogenic effects of ethanol in mouse models. Alcoholism, clinical and experimental research. 2003;27(9):1499-506.
Cyrus T, Yao Y, Rokach J, Tang LX, Pratico D. Vitamin E reduces progression of atherosclerosis in low-density lipoprotein receptor-deficient mice with established vascular lesions. Circulation. 2003;107(4):521-3.
Schreyer SA, Vick C, Lystig TC, Mystkowski P, LeBoeuf RC. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. American journal of physiology Endocrinology and metabolism. 2002;282(1):E207-14.
Schiller NK, Boisvert WA, Curtiss LK. Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations. Arteriosclerosis, thrombosis, and vascular biology. 2002;22(8):1341-6.
Hockings PD, Roberts T, Galloway GJ, Reid DG, Harris DA, Vidgeon-Hart M, et al. Repeated three-dimensional magnetic resonance imaging of atherosclerosis development in innominate arteries of low-density lipoprotein receptor-knockout mice. Circulation. 2002;106(13):1716-21.
Devlin CM, Kuriakose G, Hirsch E, Tabas I. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(9):6280-5.
Aiello RJ, Bourassa PA, Lindsey S, Weng W, Freeman A, Showell HJ. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arteriosclerosis, thrombosis, and vascular biology. 2002;22(3):443-9.
Schiller NK, Kubo N, Boisvert WA, Curtiss LK. Effect of gamma-irradiation and bone marrow transplantation on atherosclerosis in LDL receptor-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2001;21(10):1674-80.
Laurila A, Cole SP, Merat S, Obonyo M, Palinski W, Fierer J, et al. High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice. Arteriosclerosis, thrombosis, and vascular biology. 2001;21(6):991-6.
Dichek HL, Johnson SM, Akeefe H, Lo GT, Sage E, Yap CE, et al. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. Journal of lipid research. 2001;42(2):201-10.
Cyrus T, Tang LX, Rokach J, FitzGerald GA, Pratico D. Lipid peroxidation and platelet activation in murine atherosclerosis. Circulation. 2001;104(16):1940-5.
Tsimikas S, Shortal BP, Witztum JL, Palinski W. In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression. Arteriosclerosis, thrombosis, and vascular biology. 2000;20(3):689-97.
Tacken PJ, Teusink B, Jong MC, Harats D, Havekes LM, van Dijk KW, et al. LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice. Journal of lipid research. 2000;41(12):2055-62.
Pratico D, Cyrus T, Li H, FitzGerald GA. Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis. Blood. 2000;96(12):3823-6.
Merat S, Fruebis J, Sutphin M, Silvestre M, Reaven PD. Effect of aging on aortic expression of the vascular cell adhesion molecule-1 and atherosclerosis in murine models of atherosclerosis. The journals of gerontology Series A, Biological sciences and medical sciences. 2000;55(2):B85-94.
Prescott MF, Sawyer WK, Von Linden-Reed J, Jeune M, Chou M, Caplan SL, et al. Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury. Annals of the New York Academy of Sciences. 1999;878:179-90.
Merat S, Casanada F, Sutphin M, Palinski W, Reaven PD. Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet. Arteriosclerosis, thrombosis, and vascular biology. 1999;19(5):1223-30.
Marsh MM, Walker VR, Curtiss LK, Banka CL. Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice. Journal of lipid research. 1999;40(5):893-900.
Lichtman AH, Clinton SK, Iiyama K, Connelly PW, Libby P, Cybulsky MI. Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arteriosclerosis, thrombosis, and vascular biology. 1999;19(8):1938-44.
Towler DA, Bidder M, Latifi T, Coleman T, Semenkovich CF. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. The Journal of biological chemistry. 1998;273(46):30427-34.
Sakaguchi H, Takeya M, Suzuki H, Hakamata H, Kodama T, Horiuchi S, et al. Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice. Laboratory investigation; a journal of technical methods and pathology. 1998;78(4):423-34.
Kirk EA, Sutherland P, Wang SA, Chait A, LeBoeuf RC. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. The Journal of nutrition. 1998;128(6):954-9.
Crawford RS, Kirk EA, Rosenfeld ME, eBoeuf RC, Chait A. Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse. Arteriosclerosis, thrombosis, and vascular biology. 1998;18(9):1506-13.
Dai J, Miller BA, Lin RC. Alcohol feeding impedes early atherosclerosis in low-density lipoprotein receptor knockout mice: factors in addition to high-density lipoprotein-apolipoprotein A1 are involved. Alcoholism, clinical and experimental research. 1997;21(1):11-8.
Sinnis P, Willnow TE, Briones MR, Herz J, Nussenzweig V. Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes. The Journal of experimental medicine. 1996;184(3):945-54.
Mortimer BC, Beveridge DJ, Martins IJ, Redgrave TG. Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. The Journal of biological chemistry. 1995;270(48):28767-76.
Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. The Journal of clinical investigation. 1994;93(5):1885-93.
Rudling M. Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vivo. Journal of lipid research. 1992;33(4):493-501.