动脉粥样硬化模型
鹌鹑动脉粥样硬化模型饲料
和造模注意事项
Model Diet of Atherosclerosis in
Quails
大量研究采用鹌鹑(quail)研究动脉粥样硬化和用于动脉粥样硬化模型复制。研究中多采用日本鹌鹑。
一、鹌鹑动脉粥样硬化模型造模的特点
鹌鹑作为人类动脉粥样硬化模型动物，具有以下方面的表现：
(1)鹌鹑的血浆胆固醇浓度对饲料中胆固醇很敏感；
(2)模型饲料引起的血浆胆固醇升高，主要是在LDL和VLDL；
(3)血浆胆固醇浓度升高与动脉粥样硬化的严重程度关联。
(4)动脉粥样硬化斑块形成类似人类动脉粥样硬化的高级阶段，包括内膜增厚、水肿、坏死、肥厚，动脉狭窄，梗死。
(5)动脉粥样硬化模型的重复性好。
二、鹌鹑动脉粥样硬化模型造模方法和模型饲料
鹌鹑动脉粥样硬化模型饲料包括：高脂高胆固醇模型饲料，高胆固醇模型饲料。右图是鹌鹑动脉粥样硬化模型发展程度与血浆胆固醇的关系。因此，鹌鹑的动脉粥样硬化最为关键的是血浆胆固醇浓度，只要升高血浆胆固醇，动脉粥样硬化发展只是迟早的事。
1.鹌鹑动脉粥样硬化用高胆固醇模型饲料
从图中可以看到，鹌鹑的动脉粥样硬化发展程度与血浆胆固醇浓度成正比。因此，选用高胆固醇模型饲料时，如果希望成模更快，应当选择胆固醇含量较高的模型饲料。
但是，模型饲料中胆固醇含量较高时，血浆胆固醇浓度过高，可能引起动物摄食量降低。
下面是南通特洛菲饲料科技有限公司生产的适用于鹌鹑动脉粥样硬化的高胆固醇模型饲料。
鹌鹑高胆固醇模型饲料
日粮型
以下模型饲料是在本公司鹌鹑标准饲料(低脂)生产过程中添加胆固醇，其正常对照饲料应当选用相应的低脂型鹌鹑标准饲料。
产品代码 模型饲料名称 说明
TP 3Q002：鹌鹑高胆固醇模型饲料，0.5%胆固醇
TP 3Q004：鹌鹑高胆固醇模型饲料，1%胆固醇
TP 3Q006：鹌鹑高胆固醇模型饲料，2%胆固醇
TP 3Q008：鹌鹑高胆固醇模型饲料，3%胆固醇
TP 3Q010：鹌鹑高胆固醇模型饲料，4%胆固醇
TP 3Q012：鹌鹑高胆固醇模型饲料，5%胆固醇
如果以上模型饲料不能满足你的要求，请提出！
纯化型
以下模型饲料是纯化日粮，价格相对较高。
产品代码 模型饲料名称 说明
TP 3Q104：鹌鹑高胆固醇模型饲料，0.5%胆固醇
TP 3Q104：鹌鹑高胆固醇模型饲料，1%胆固醇
TP 3Q106：鹌鹑高胆固醇模型饲料，2%胆固醇
如果以上模型饲料不能满足你的要求，请提出！
2.鹌鹑动脉粥样硬化用高脂高胆固醇模型饲料
给鹌鹑高脂高胆固醇模型饲料，血浆胆固醇浓度比高胆固醇饲料喂养的鹌鹑要大幅度提高。因此，应当优先考虑选用高脂高胆固醇模型饲料。
下表列出的是南通特洛菲饲料科技有限公司生产的鹌鹑动脉粥样硬化用高脂高胆固醇模型饲料。
鹌鹑高脂高胆固醇模型饲料
日粮型
以下模型饲料是在本公司鹌鹑标准饲料(低脂)生产过程中添加脂肪和胆固醇，其正常对照饲料应当选用相应的标准饲料。
产品代码 模型饲料名称 说明
TP 3Q204：鹌鹑高脂高胆固醇饲料，5%脂肪，0.5%胆固醇
TP 3Q206：鹌鹑高脂高胆固醇饲料，5%脂肪，2%胆固醇
TP 3Q209：鹌鹑高脂高胆固醇饲料，12%脂肪，0.5%胆固醇
TP 3Q212：鹌鹑高脂高胆固醇饲料，15%脂肪，0.5%胆固醇
TP 3Q214：鹌鹑高脂高胆固醇饲料，15%脂肪，2%胆固醇
如果以上模型饲料不能满足你的要求，请提出！
纯化型
以下模型饲料是纯化日粮，价格相对较高。
产品代码 模型饲料名称 说明
TP 3Q304：鹌鹑高脂高胆固醇饲料，5%脂肪，0.5%胆固醇
TP 3Q306：鹌鹑高脂高胆固醇饲料，5%脂肪，2%胆固醇
TP 3Q309：鹌鹑高脂高胆固醇饲料，12%脂肪，0.5%胆固醇
TP 3Q312：鹌鹑高脂高胆固醇饲料，15%脂肪，0.5%胆固醇
TP 3Q314：鹌鹑高脂高胆固醇饲料，15%脂肪，2%胆固醇
如果以上模型饲料不能满足你的要求，请提出！
对于上述描述中有不清楚之处或者其他注意事项，请与南通特洛菲饲料科技有限公司技术部联系。
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