返回
当前专题

TP4063:Rao-Larkin酒精液体模型饲料
Rao-Larkin Ethanol Liquid Diet(26% ethanol, TP4063)

一、Rao-Larkin ethanol liquid diet(26% ethanol)介绍


Rao的课题组针对Lieber-DeCarli标准型(regular型)酒精液体模型饲料进行了大量研究,提出了大量的证据证明标准型Lieber-DeCarli酒精液体饲料引起的脂肪肝与营养不良有关,关键原因是,酒精导致大鼠厌食症,从而摄入营养素不足,最为有力的证据是:

(1)关于脂肪肝的观察

用36%酒精喂养造成脂肪肝的动物改用26%酒精液体饲料,脂肪肝消退或减轻,反过来,26%酒精液体饲料喂养后的动物没有出现脂肪肝,此时转为喂养36%酒精时,动物出现脂肪肝。

(2)动物的酒精摄入量和血液酒精浓度

比起36%酒精液体饲料的喂养,26%酒精液体饲料喂养时动物摄入饲料量要多(热量摄入要高),酒精摄入量要多,但血液酒精浓度却是降低。

(3)与颗粒型(棒状)标准饲料比较

与颗粒型标准饲料喂养的动物比较,36%酒精液体饲料喂养后,体重增加速度较小。

他们认为,动物属于营养素缺乏状态可以介绍以上(2)和(3),而(1)中36%酒精液体饲料引起的所谓酒精性脂肪脂肪肝实际上由于酒精引起厌食症,使得摄入热量不足,并且因为摄入量过低导致营养素摄入量不足,从而出现了营养素缺乏,引起肝脏代谢发生改变和脂肪肝,而血液酒精浓度之所以要比26%酒精液体饲料要高的原因正是因为营养素相对不足所致酒精分解代谢减少。

此外,他们认为,除了酒精性脂肪肝模型之外,其他方面的研究不应该采用36%酒精的高脂液体饲料,而应该改用26%的酒精水平。这就是这里所称的Rao-Larkin酒精液体饲料。

Rao-Larkin酒精液体模型饲料
【1】Rao-Larkin酒精液体模型饲料:

脂肪35%, 蛋白质18%, 碳水化合物21%, 酒精26%。

南通特洛菲饲料科技有限公司模型饲料代码:TP4063;

【2】Rao-Larkin酒精液体对照饲料:

脂肪35%, 蛋白质18%, 碳水化合物47%。

南通特洛菲饲料科技有限公司对照饲料代码:TP4063C;

二、TP4063(Rao-Larkin)ethanol liquid diet的用途


从以上可知,TP4063适合于除了酒精性脂肪肝造模之外酒精的效应及其机制的研究。

Rao-Larkin酒精液体模型饲料的用途
广泛应用于大鼠、小鼠、兔、地鼠等动物:

(1)酒精性肝损伤的复制;

(2)酒精性肝损伤模型的复制;

(3)酒精性胰腺炎模型的复制

(4)药物、食品功能因子、保健食品对酒精性肝损伤的保护或对抗作用;

(5)药物、食品功能因子、保健食品对酒精的解毒作用;

(6)酒精成瘾的机制;

(7)酒精所致生理机能的改变及其机制。

(8)酒精与毒素(环境、食物、微生物的毒素)对机体的相互作用。

请注意动物不同种系、品系、年龄、性别的差异。

三、TP4063购买的注意点


关于Lieber-DeCarli酒精液体模型饲料的详细介绍,请点击“Lieber-DeCarli酒精液体饲料和注意事项”。

1.购买饲料前:

(1)应当做好动物的准备,注意动物的品种、品系、年龄、性别的选择。

(2)准备好喂养流程的准备。

2. 购买后应当及时向公司索取以下资料:

《液体饲料配制方法》

《酒精液体饲料喂养方法》

《怎样根据研究的需要调整酒精的配比》

 

References:

Samudio-Ruiz SL, Allan AM, Sheema S, Caldwell KK. Hippocampal N-methyl-D-aspartate receptor subunit expression profiles in a mouse model of prenatal alcohol exposure. Alcohol Clin Exp Res. 2010 Feb;34(2):342-53.

Chakkalakal DA, Novak JR, Fritz ED, Mollner TJ, McVicker DL, Garvin KL, McGuire MH, Donohue TM. Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption. Alcohol. 2005 Jul;36(3):201-14.

Wyatt TA, Gentry-Nielsen MJ, Pavlik JA, Sisson JH. Desensitization of PKA-stimulated ciliary beat frequency in an ethanol-fed rat model of cigarette smoke exposure. Alcohol Clin Exp Res. 2004 Jul;28(7):998-1004.

Gentry-Nielsen MJ, Top EV, Snitily MU, Casey CA, Preheim LC. A rat model to determine the biomedical consequences of concurrent ethanol ingestion and cigarette smoke exposure. Alcohol Clin Exp Res. 2004 Jul;28(7):1120-8.

Frishman WH, Del Vecchio A, Sanal S, Ismail A. Cardiovascular manifestations of substance abuse: part 2: alcohol, amphetamines, heroin, cannabis, and caffeine. Heart Dis. 2003 Jul-Aug;5(4):253-71.

Costa ET, Olivera DS, Meyer DA, Ferreira VM, Soto EE, Frausto S, Savage DD, Browning MD, Valenzuela CF. Fetal alcohol exposure alters neurosteroid modulation of hippocampal N-methyl-D-aspartate receptors. J Biol Chem. 2000 Dec 8;275(49):38268-74.

Costa ET, Olivera DS, Meyer DA, Ferreira VM, Soto EE, Frausto S, Savage DD, Browning MD, Valenzuela CF. Fetal alcohol exposure alters neurosteroid modulation of hippocampal N-methyl-D-aspartate receptors. J Biol Chem. 2000 Dec 8;275(49):38268-74.

Rao GA, Larkin EC. Nutritional factors required for alcoholic liver disease in rats. J Nutr. 1997 May;127(5 Suppl):896S-898S.

Allan AM, Wu H, Paxton LL, Savage DD. Prenatal ethanol exposure alters the modulation of the gamma-aminobutyric acidA1 receptor-gated chloride ion channel in adult rat offspring. J Pharmacol Exp Ther. 1998 Jan;284(1):250-7.

Sankaran H, Deveney CW, Larkin EC, Rao GA. Carbohydrate intake determines pancreatic acinar amylase activity and release despite chronic alcoholemia in rats. J Nutr. 1992 Sep;122(9):1884-91.

Derr RF, Draves K. Prevention of alcohol toxicity by adequate nutrients: mechanism and potential application. Nutr Res 1990, 10(11):1285-1297.

López JM, Bombi JA, Valderrama R, Giménez A, Parés A, Caballería J, Imperial S, Navarro S. Effects of prolonged ethanol intake and malnutrition on rat pancreas. Gut. 1996 Feb;38(2):285-92.

Derr RF. The quantities of nutrients recommended by the NRC abate the effects of a toxic alcohol dose administered to rats. J Nutr. 1989 Aug;119(8):1228-30.

Preedy VR, Duane P, Peters TJ. Biological effects of chronic ethanol consumption: a reappraisal of the Lieber-De Carli liquid-diet model with reference to skeletal muscle. Alcohol Alcohol. 1988;23(2):151-4.

Rao GA, Larkin EC. Inadequate intake by growing rats of essential nutrients from liquid diets used for chronic alcohol consumption. Nutr Res, 1985; 5(7):789-796.

Rao GA, Riley DE, Larkin E. Lieber-decarli alcohol diet modification to enhance growth in young rats. Nutr Res,1986,6(1):101–105.

Nguyen T, Chi CW, Larkin EC, Rao GA. Low liver glycogen content in alcoholic rats due to depressed carbohydrate ingestion. Biochem Arch 1990 6(2):217-221 .

Sankaran H, Desai AJ, Deveney CW, Larkin EC, Rao GA. Energy restriction and chronic alcoholemia prolong the delay in gastric emptying in rats. Nutr Res,1996, 16(5):855-864.

Sankaran H, Deveney CW, Larkin EC, Rao GA. Carbohydrate intake determines pancreatic acinar amylase activity and release despite chronic alcoholemia in rats. J. Nutr. 1992, 122: 1884–1891.

Rao GA, Larkin EC, Derr RF.Chronic alcohol consumption during pregnancy: alleviation of untoward effects by adequate nutrition. Nutr Res, 1988,8(4):421–429.



有困惑?那就商量呗!

液体饲料的优点,你可以充分运用!

---------《》-------

marker可以任意缺乏或过载某营养素

marker可以任意添加药物或测试成分

marker可以精确定量饲料摄入量

marker可以任意定制饲料


小帮手
关闭
收藏本网站