灵长类(猴子、猩猩、狒狒，等)Lieber-DeCarli酒精液体饲料
Ethanol Liquid Diet for Primate(baboon, monkey, chimpanzee)
一、灵长类酒精液体饲料的用途
【1】酒精对生理机能；
【2】任何酒精性疾病的造模，尤其是酒精性脂肪肝、酒精性肝硬化，等等；
【3】酒精毒性和毒理学的研究；
【4】药物、食品功能因子、保健品对酒精的拮抗作用；
【5】疾病造模后药物、食品功能因子、保健品的治疗或者辅助治疗效果及其机制；
【6】毒物与酒精在机体的相互作用。的相互作用。
酒精液体模型饲料的特点：【1】与一般实验动物相比，酒精热量和血液酒精浓度可以很高；
【2】饲料配比与人类饮食相似。
二、灵长类Lieber-DeCarli酒精液体模型饲料
TP4700：脂肪21%, 蛋白质18%, 碳水化合物11%, 酒精50%。
TP4700C：TP4700的对照饲料，脂肪21%, 蛋白质18%, 碳水化合物61%。
你还可以根据研究需要定制任意组成！
The composition of the liquid diet is adjusted to meet the needs of the primate. The protein content is almost twice the amount recommended for humans. The carbohydrate content is 61% of total calories in the control diet. In the alcohol-containing diet, ethanol replaces carbohydrate isocalorically up to 50% of total energy. Thus, the alcohol content of the primate liquid diet is significantly higher than that of the rat because of a lesser aversion to ethanol in the former species. The higher alcohol intake, coupled with the longer periods of administration, may, in addition to species difference, be responsible for the fact that the primate not only develops fatty liver, but progresses to more severe stages of alcoholic liver disease, including cirrhosis. Diets are given to the primate in standard drinking bottles equipped with an outlet valve. Except for a daily carrot, the animals receive nothing to eat or drink but the liquid diet.。
References：
Seth D, Gorrell MD, McGuinness PH, Leo MA, Lieber CS, McCaughan GW, Haber PS. SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. J Biochem Biophys Methods. 2003 Jan 31;55(1):53-66.
Lieber CS, Leo MA, Cao Q, Ren C, DeCarli LM. Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. J Clin Gastroenterol. 2003 Oct;37(4):336-9.
Seth D, Leo MA, McGuinness PH, Lieber CS, Brennan Y, Williams R, Wang XM, McCaughan GW, Gorrell MD, Haber PS. Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver. Am J Pathol. 2003 Dec;163(6):2303-17.
Ren C, Paronetto F, Mak KM, Leo MA, Lieber CS. Cytokeratin 7 staining of hepatocytes predicts progression to more severe fibrosis in alcohol-fed baboons. J Hepatol. 2003 Jun;38(6):770-5.
Navder KP, Baraona E, Leo MA, Lieber CS. Oxidation of LDL in baboons is increased by alcohol and attenuated by polyenylphosphatidylcholine. J Lipid Res. 1999 Jun;40(6):983-7.
Lieber CS, Leo MA, Aleynik SI, Aleynik MK, DeCarli LM. Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcohol Clin Exp Res. 1997 Apr;21(2):375-9.
Pawlosky RJ, Flynn BM, Salem N Jr. The effects of low dietary levels of polyunsaturates on alcohol-induced liver disease in rhesus monkeys. Hepatology 1997;26:1386-1392.
Pawlosky RJ, Salem N Jr. A chronic ethanol-feeding study in rhesus monkeys. Lipids 1999;34:S131-S132
Lieber CS, DeCarli LM, Mak KM, Kim CI, Leo MA. Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin. Hepatology. 1990 Dec;12(6):1390-8.
Lieber CS, Leo MA, Mak KM, DeCarli LM, Sato S. Choline fails to prevent liver fibrosis in ethanol-fed baboons but causes toxicity. Hepatology. 1985 Jul-Aug;5(4):561-72.
Nakano M, Lieber CS. Ultrastructure of initial stages of perivenular fibrosis in alcohol-fed baboons.Am J Pathol. 1982 Feb;106(2):145-55.
Porto LC, Chevallier M, Grimaud JA. Morphometry of terminal hepatic veins. 2. Follow up in chronically alcohol-fed baboons. Virchows Arch A Pathol Anat Histopathol. 1989;414(4):299-307.
Lieber CS, DeCarli LM. Animal models of chronic ethanol toxicity. Method Enzymol 1994;233:585-594
Ainley CC, Senapati A, Brown IM, Iles CA, Slavin BM, Mitchell WD, Davies DR, Keeling PW, Thompson RP. Is alcohol hepatotoxic in the baboon? J Hepatol. 1988 Aug;7(1):85-92.
Mak KM, Leo MA, Lieber CS. Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells.Gastroenterology. 1984 Jul;87(1):188-200.
Lieber CS, Robins SJ, Li J, DeCarli LM, Mak KM, Fasulo JM, Leo MA. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology. 1994 Jan;106(1):152-9.
Lieber CS, Casini A, DeCarli LM, Kim CI, Lowe N, Sasaki R, Leo MA. S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon.Hepatology. 1990 Feb;11(2):165-72
Holmes RS, Meyer J, VandeBerg JL. Baboon alcohol dehydrogenase isozymes: purification and properties of liver class I ADH. Moderate alcohol consumption reduces liver class I and class II ADH activities.Prog Clin Biol Res. 1990;344:819-41.
Holmes RS, Meyer J, VandeBerg JL.Baboon alcohol dehydrogenase isozymes: purification and properties of liver class I ADH. Moderate alcohol consumption reduces liver class I and class II ADH activities.Prog Clin Biol Res. 1990;344:819-41.
Holmes RS, VandeBerg JL. Baboon alcohol dehydrogenase isozymes: phenotypic changes in liver following chronic consumption of alcohol. Isozymes Curr Top Biol Med Res. 1987;16:1-20.
Popper H, Lieber CS. Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am J Pathol 1980;98:695-716.
Porto LC, Chevallier M, Grimaud JA. Morphometry of terminal hepatic veins. 2. Follow up in chronically alcohol-fed baboons. Virchows Arch 1989; 414:299-307.
Holmes RS, Courtney YR, VandeBerg JL. Alcohol dehydrogenase isozymes in baboons: tissue distribution, catalytic properties, and variant phenotypes in liver, kidney, stomach, and testis.Alcohol Clin Exp Res. 1986 Dec;10(6):623-30.
Altomare E, Leo MA, Sato C, Vendemiale G, Lieber CS.Interaction of ethanol with acetaminophen metabolism in the baboon. Biochem Pharmacol. 1984 Jul 15;33(14):2207-12.
Mezey E, Potter JJ, French SW, Tamura T, Halsted CH. Effect of chronic ethanol feeding on hepatic collagen in the monkey. Hepatology 1983;3:41-44.
Sato M, Lieber CS. Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats. J Nutr. 1981 Nov;111 (11):2015-23.
Rogers AE, Fox JG, Murphy JC. Ethanol and diet interactions in male rhesus monkeys. Drug Nutr Interact 1981;1:3-14
Lieber CS, Decarli LM. Animal models of ethanol dependence and liver injury in rats and baboons. Fed Proc. 1976 Apr;35 (5):1232-6.
Lieber CS, DeCarli L, Rubin E. Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc Natl Acad Sci U S A. 1975 Feb;72(2):437-41.
Lieber CS, DeCarli LM. Alcoholic liver injury: experimental models in rats and baboons. Adv Exp Med Biol. 1975;59:379-93.
Lieber, C. S. & De Carli, L. M. An experimental model of alcohol feeding and liver injury in the baboon. J. Med. Prim. 1974;3, 153-163.
---------《》-------
可以任意缺乏或过载某营养素
可以任意添加药物或测试成分
可以精确定量饲料摄入量
可以任意定制饲料
- AIN76酒精液体饲料(TP4000)
- AIN93G酒精液体饲料(TP4010)
- AIN93M酒精液体饲料(TP4020)
- 标准型Lieber-DeCarli酒精液体饲料(TP4030)
- 43%高脂肪型Lieber-DeCarli酒精液体饲料(TP4039)
- 12%低脂型Lieber-DeCarli酒精液体饲料(TP4032)
- 10%低脂肪型Lieber-DeCarli酒精液体饲料(TP4031)
- 5%低脂型Lieber-DeCarli酒精液体饲料(TP4033)
- 2%低脂型Lieber-DeCarli酒精液体饲料(TP4034)
- 25%高蛋白型Lieber-DeCarli酒精液体饲料(TP4035)
- 12.5%低蛋白型Lieber-DeCarli酒精液体饲料(TP4036)
- 4%低蛋白型Lieber-DeCarli酒精液体饲料(TP4038)
- 2%低蛋白型Lieber-DeCarli酒精液体饲料(TP4037)
- 26%酒精Rao-Larkin酒精液体饲料(TP4063)
- 40%酒精高脂Nanji液体饲料(TP4054)
- 29%酒精高脂Nanji液体饲料(TP4062)
- Lindros酒精液体饲料(TP4060)
- Lieber-DeCarli酒精液体饲料25%高蛋白型
- Weinberg-Keiver酒精液体饲料(TP4040)
- Yeh-Cerklewski酒精液体饲料(TP4100)
- Sahchis酒精液体饲料(TP4230)
- Wiener酒精液体饲料(TP4200)
- Tsukamoto-French模型酒精液体饲料
- Thompson-Reitz酒精液体模型饲料(TP5100)
- Badger酒精液体饲料
- 微型猪（小型猪）酒精液体饲料
- 灵长类Lieber-DeCarli酒精液体饲料(TP7000)