返回
当前专题

Weinberg/Keiver酒精液体模型饲料
Weinberg/Keiver Ethanol Liquid Diet(TP4040)

一、Weinberg/Keiver ethanol liquid Diet介绍


Weinberg/Keiver酒精液体模型饲料
【1】Weinberg/Keiver酒精液体模型饲料:

脂肪16.4%,蛋白质25%,碳水化合物23.1%,酒精35.5%。

南通特洛菲饲料科技有限公司生产的该模型饲料的代码:TP4040;

【2】Weinberg/Keiver酒精液体对照饲料:

脂肪16.4%, 蛋白质25%, 碳水化合物58.6%。

南通特洛菲饲料科技有限公司生产的该对照饲料的代码:TP4040C;

Weinberg/Keiver酒精液体模型饲料是一种高蛋白型酒精液体造模饲料,专用于妊娠期和哺乳期大鼠或小鼠。该饲料是在Lieber-DeCarli酒精液体饲料(Regular型,标准型)基础上提高蛋白质含量,降低脂肪含量,而酒精含量维持不变。

Lieber-DeCarli高蛋白型酒精液体饲料中也有一款高蛋白型酒精液体模型饲料,蛋白质含量也是25%,也是用于Weinberg/Keiver酒精液体模型饲料。Weinberg/Keiver酒精液体模型饲料与Lieber-DeCarli高蛋白型酒精液体饲料的区别在于脂肪含量不同,营养素更平衡。

二、Weinberg/Keiver ethanol liquid Diet的用途


Weinberg/Keiver酒精液体模型饲料的用途
广泛应用于妊娠期和哺乳期:

(1)酒精对母体生理机能的作用;

(2)酒精对母体营养的作用;

(3)酒精对胚胎发育的作用及其机理;

(4)酒精对后代的发育以及成年后生理机能的影响;

(5)胎儿酒精(中毒)综合症(Fetal alcohol syndrome,简称FAS)或(fetal alcohol spectrum disorder,FASD)或(FASARD Fetal alcohol syndrome and related disorders,FASRD)发病机理的研究,或用于FAS或FASD造模进行治疗或干预的研究;

(6)酒精对后来成瘾的联系。

请注意不同种系和品系的差异。

三、Weinberg/Keiver ethanol liquid Diet应用的注意点


1.购买饲料前:

(1)应当做好动物的准备,注意动物的品种和品系的选择。

(2)如果用于妊娠期,应当准备好妊娠方法的流程准备。

2. 购买前、后应当向公司索取以下资料:

《液体饲料配制方法》

《酒精液体饲料喂养方法》

《怎样根据研究的需要调整酒精的配比》

 

References:

[1] Patten AR, Brocardo PS, Christie BR. Omega-3 supplementation can restore glutathione levels and prevent oxidative damage caused by prenatal ethanol exposure. J Nutr Biochem. 2013 May;24(5):760-9.

[2] Sickmann HM, Patten AR, Morch K, Sawchuk S, Zhang C, Parton R, Szlavik L, Christie BR. Prenatal ethanol exposure has sex-specific effects on hippocampal long-term potentiation. Hippocampus. 2014 Jan;24(1):54-64.

[3] Titterness AK, Christie BR. Prenatal ethanol exposure enhances NMDAR-dependent long-term potentiation in the adolescent female dentate gyrus. Hippocampus. 2012 Jan;22(1):69-81.

[4] Sinha P, Halasz I, Choi JF, McGivern RF, Redei E. Maternal adrenalectomy eliminates a surge of plasma dehydroepiandrosterone in the mother and attenuates the prenatal testosterone surge in the male fetus. Endocrinology. 1997 Nov;138(11):4792-7.

[5] Weinberg J. 1989. Prenatal ethanol exposure alters adrenocortical development of offspring. Alcohol Clin Exp Res 13: 73–83.

[6] Weinberg J,Gallo PV. 1982. Prenatal ethanol exposure: Pituitary-adrenal activity in pregnant dams and offspring. Neurobehav Toxicol Teratol 4: 515–520.

[7] Patten AR, Sickmann HM, Dyer RA, Innis SM, Christie BR. Omega-3 fatty acids can reverse the long-term deficits in hippocampal synaptic plasticity caused by prenatal ethanol exposure. Neurosci Lett. 2013 Sep 13;551:7-11.

[8] Patten AR, Brocardo PS, Sakiyama C, Wortman RC, Noonan A, Gil-Mohapel J, Christie BR. Impairments in hippocampal synaptic plasticity following prenatal ethanol exposure are dependent on glutathione levels. Hippocampus. 2013 Dec;23(12):1463-75.

[9] Anna R. Patten, Joana Gil-Mohapel, Ryan C. Wortman, Athena Noonan,Patricia S. Brocardo and Brian R. Christie. Effects of ethanol exposure during eistinct periods of brain development on hippocampal synaptic plasticity. Brain Sci. 2013, 3(3), 1076-1094.

[10] Allan AM, Weeber EJ, Savage DD, Caldwell KK. Effects of prenatal ethanol exposure on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of adult rat offspring.Alcohol Clin Exp Res. 1997 Nov;21(8):1534-41.

[11] Allan AM, Wu H, Paxton LL, Savage DD. Prenatal ethanol exposure alters the modulation of the gamma-aminobutyric acidA1 receptor-gated chloride ion channel in adult rat offspring. J Pharmacol Exp Ther. 1998 Jan;284(1):250-7.

[12] Savage DD, Becher M, de la Torre AJ, Sutherland RJ. Dose-dependent effects of prenatal ethanol exposure on synaptic plasticity and learning in mature offspring. Alcohol Clin Exp Res. 2002 Nov;26(11):1752-8.

[13] Galindo R, Frausto S, Wolff C, Caldwell KK, Perrone-Bizzozero NI, Savage DD. Prenatal ethanol exposure reduces mGluR5 receptor number and function in the dentate gyrus of adult offspring. Alcohol Clin Exp Res. 2004 Oct;28(10):1587-97.

[14] Zhang X, Lan N, Bach P, Nordstokke D, Yu W, Ellis L, Meadows GG, Weinberg J. Prenatal alcohol exposure alters the course and severity of adjuvant-induced arthritis in female rats. Brain Behav Immun. 2012 Mar;26(3):439-50.

[15] Yirmiya R, Chiappelli F, Tio DL, Tritt SH, Taylor AN. Effects of prenatal alcohol and pair feeding on lipopolysaccharide-induced secretion of TNF-alpha and corticosterone. Alcohol. 1998 May;15(4):327-35.

[16] Ward IL, Bennett AL, Ward OB, Hendricks SE, French JA. Androgen threshold to activate copulation differs in male rats prenatally exposed to alcohol, stress, or both factors. Horm Behav. 1999 Oct;36(2):129-40.

[17] Ward IL, Ward OB, French JA, Hendricks SE, Mehan D, Winn RJ. Prenatal alcohol and stress interact to attenuate ejaculatory behavior, but not serum testosterone or LH in adult male rats. Behav Neurosci. 1996 Dec;110(6):1469-77.

[18] Ward OB, Ward IL, Denning JH, Hendricks SE, French JA. Hormonal mechanisms underlying aberrant sexual differentiation in male rats prenatally exposed to alcohol, stress, or both. Arch Sex Behav. 2002 Feb;31(1):9-16.

[19] Ward IL, Ward OB, Winn RJ, Bielawski D. Male and female sexual behavior potential of male rats prenatally exposed to the influence of alcohol, stress, or both factors. Behav Neurosci. 1994 Dec;108(6):1188-95.

[20] Ward IL, Romeo RD, Denning JH, Ward OB.Fetal alcohol exposure blocks full masculinization of the dorsolateral nucleus in rat spinal cord. Physiol Behav. 1999 Jun;66(4):571-5.

[21] Ward OB, Ward IL, Denning JH, French JA, Hendricks SE.Postparturitional testosterone surge in male offspring of rats stressed and/or fed ethanol during late pregnancy.Horm Behav. 2002 Mar;41(2):229-35.

[22] Uban KA, Sliwowska JH, Lieblich S, Ellis LA, Yu WK, Weinberg J, Galea LA. Prenatal alcohol exposure reduces the proportion of newly produced neurons and glia in the dentate gyrus of the hippocampus in female rats.Horm Behav. 2010 Nov;58(5):835-43.

[23] Sliwowska JH, Barker JM, Barha CK, Lan N, Weinberg J, Galea LA. Stress-induced suppression of hippocampal neurogenesis in adult male rats is altered by prenatal ethanol exposure.Stress. 2010 Jul;13(4):301-13.

[24] Sadrian B, Wilson DA, Saito M. Long-lasting neural circuit dysfunction following developmental ethanol exposure. Brain Sci. 2013 Apr 29;3(2):704-727.

[25] Redila VA, Olson AK, Swann SE, Mohades G, Webber AJ, Weinberg J, Christie BR. Hippocampal cell proliferation is reduced following prenatal ethanol exposure but can be rescued with voluntary exercise. Hippocampus. 2006;16(3):305-11.

[27] McGivern RF, Ervin MG, McGeary J, Somes C, Handa RJ. Prenatal ethanol exposure induces a sexually dimorphic effect on daily water consumption in prepubertal and adult rats. Alcohol Clin Exp Res. 1998 Jun;22(4):868-75.

[28] McGivern RF, Handa RJ, Raum WJ. Ethanol exposure during the last week of gestation in the rat: inhibition of the prenatal testosterone surge in males without long-term alterations in sex behavior. Neurotoxicol Teratol. 1998 Jul-Aug;20(4):483-90.

[29] Aird F, Halasz I, Redei E. Ontogeny of hypothalamic corticotropin-releasing factor and anterior pituitary pro-opiomelanocortin expression in male and female offspring of alcohol-exposed and adrenalectomized dams. Alcohol Clin Exp Res. 1997 Dec;21(9):1560-6.

[30] Wilson ME, Handa RJ.Gonadotropin secretion in infantile rats exposed to ethanol in utero.Alcohol. 1997 Sep-Oct;14(5):497-501.

[31] Handa RJ, Zuloaga DG, McGivern RF. Prenatal ethanol exposure alters core body temperature and corticosterone rhythms in adult male rats. Alcohol. 2007 Dec;41(8):567-75.

[32] Allen GC, Farnell YZ, Maeng JU, West JR, Chen WJ, Earnest DJ. Long-term effects of neonatal alcohol exposure on photic reentrainment and phase-shifting responses of the activity rhythm in adult rats. Alcohol. 2005 Oct;37(2):79-88.

[33] Glavas MM, Ellis L, Yu WK, Weinberg J. Effects of prenatal ethanol exposure on basal limbic-hypothalamic-pituitary-adrenal regulation: role of corticosterone. Alcohol Clin Exp Res. 2007 Sep;31(9):1598-610.

[34] Farnell YZ, Allen GC, Neuendorff N, West JR, Wei-Jung AC, Earnest DJ. Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus. Alcohol. 2009 Aug;43(5):387-96.

[35] Osborn JA, Yu C, Stelzl GE, Weinberg J. Effects of fetal ethanol exposure on pituitary-adrenal sensitivity to secretagogues. Alcohol Clin Exp Res. 2000 Jul;24(7):1110-9.

[36] Hofmann CE, Ellis L, Yu WK, Weinberg J. Hypothalamic-pituitary-adrenal responses to 5-HT1A and 5-HT2A/C agonists are differentially altered in female and male rats prenatally exposed to ethanol. Alcohol Clin Exp Res. 2007 Feb;31(2):345-55.

[37] Glavas MM, Yu WK, Weinberg J. Effects of mineralocorticoid and glucocorticoid receptor blockade on hypothalamic-pituitary-adrenal function in female rats prenatally exposed to ethanol. Alcohol Clin Exp Res. 2006 Nov;30(11):1916-24.

[38] McGivern RF, Handa RJ, Redei E. Decreased postnatal testosterone surge in male rats exposed to ethanol during the last week of gestation. Alcohol Clin Exp Res. 1993 Dec;17(6):1215-22.

[39] McGivern RF, Handa RJ, Raum WJ. Ethanol exposure during the last week of gestation in the rat: inhibition of the prenatal testosterone surge in males without long-term alterations in sex behavior. Neurotoxicol Teratol. 1998 Jul-Aug;20(4):483-90.

[40] Ward IL, Ward OB, Affuso JD, Long WD 3rd, French JA, Hendricks SE. Fetal testosterone surge: specific modulations induced in male rats by maternal stress and/or alcohol consumption. Horm Behav. 2003 May;43(5):531-9.

[41] Rout UK, Dhossche JM. Liquid-diet with alcohol alters maternal, fetal and placental weights and the expression of molecules involved in integrin signaling in the fetal cerebral cortex. Int J Environ Res Public Health. 2010 Nov;7(11):4023-36.

[42] Weinberg J. Effects of ethanol and maternal nutritional status on fetal development. Alcohol Clin Exp Res 1985,9: 49–55.

[43] Taylor AN, Tritt SH, Tio DL, Romeo HE, Yirmiya R. Maternal adrenalectomy abrogates the effect of fetal alcohol exposure on the interleukin-1beta-induced febrile response: gender differences. Neuroendocrinology. 2002 Sep;76(3):185-92.

[44] Caldeira JC, Wu Y, Mameli M, Purdy RH, Li PK, Akwa Y, Savage DD, Engen JR, Valenzuela CF. Fetal alcohol exposure alters neurosteroid levels in the developing rat brain. J Neurochem. 2004 Sep;90(6):1530-9.

[45] Aird F, Halasz I, Redei E. Ontogeny of hypothalamic corticotropin-releasing factor and anterior pituitary pro-opiomelanocortin expression in male and female offspring of alcohol-exposed and adrenalectomized dams.Alcohol Clin Exp Res. 1997 Dec;21(9):1560-6.



有困惑?那就商量呗!

液体饲料的优点,你可以充分运用!

---------《》-------

marker可以任意缺乏或过载某营养素

marker可以任意添加药物或测试成分

marker可以精确定量饲料摄入量

marker可以任意定制饲料


小帮手
关闭
收藏本网站