动脉粥样硬化模型
- 动脉粥样硬化模型饲料和方法综述
- 大鼠、小鼠造模饲料
- 正常大鼠、小鼠模型饲料
- C57小鼠模型饲料
- 基因工程小鼠模型饲料
- 基因敲除或转基因鼠日常喂养饲料
- ApoE基因敲除(ApoE-/-)小鼠
- LDL受体基因敲除(LDLR-KO)小鼠
- ◄−−----兔模型饲料
- 地鼠模型饲料
- 豚鼠模型饲料
- 鸽子模型饲料
- 鹌鹑模型饲料
- 鸡模型饲料
- 猪或微型猪模型饲料
- 非人灵长类（猴，等）模型饲料
用于建立动脉粥样硬化模型的
兔高脂高胆固醇模型饲料(日粮型)
Atherosclerosis Model Chow with High Fat and High Cholesterol for Rabbit
在“兔动脉粥样硬化模型饲料和模型建立方法”中已经介绍了兔高脂高胆固醇模型饲料在兔动脉粥样硬化模型建立中的使用。这里进一步介绍的兔高脂高胆固醇模型饲料(日粮型）的选用。
日粮型模型饲料的优点是：与纯化型模型饲料相比，成本和价格相对便宜。然而，读者应当明白，日粮型模型饲料有其缺点：原料中含有抗氧化物质和其他生物活性物质，因此，应当尽可能选用高脂高胆固醇纯化型模型饲料。
一、兔动脉粥样硬化模型日粮型高脂肪高胆固醇模型饲料介绍
兔高脂高胆固醇饲料的关键参数有3个，一是脂肪含量，二是脂肪类型，三是胆固醇含量。
首先我们来了解南通特洛菲饲料科技有限公司用于兔动脉粥样硬化模型复制或者研究的高脂高胆固醇模型饲料情况。
兔高脂高胆固醇模型饲料（日粮型）
以下模型饲料是在本公司TP 2R001兔维持饲料(低脂)生产过程中添加脂肪和胆固醇，其正常对照饲料应当选用TP 2R001。
产品代码 模型饲料名称 在TP2R001的原料中添加
TP 2R108：兔高脂高胆固醇模型饲料--添加3%脂肪0.5%胆固醇
TP 2R110：兔高脂高胆固醇模型饲料--添加3%脂肪0.5%胆固醇
TP 2R112：兔高脂高胆固醇模型饲料--添加3%脂肪1.3%胆固醇
TP 2R112：兔高脂高胆固醇模型饲料--添加3%猪油1%胆固醇15%蛋黄粉
TP 2R116：兔高脂高胆固醇模型饲料--添加4%脂肪0.5%胆固醇
TP 2R118：兔高脂高胆固醇模型饲料--添加4%脂肪1%胆固醇
TP 2R122：兔高脂高胆固醇模型饲料--添加4.7%脂肪0.5%胆固醇
TP 2R126：兔高脂高胆固醇模型饲料--添加5%脂肪0.2%胆固醇
TP 2R128：兔高脂高胆固醇模型饲料--添加5%脂肪1%胆固醇
TP 2R130：兔高脂高胆固醇模型饲料--添加5%猪油1%胆固醇10%蛋黄粉
TP 2R132：兔高脂高胆固醇模型饲料--添加6%脂肪0.2%胆固醇
TP 2R134：兔高脂高胆固醇模型饲料--添加6%脂肪1%胆固醇
TP 2R138：兔高脂高胆固醇模型饲料--添加10%脂肪0.25%高胆固醇
TP 2R140：兔高脂高胆固醇模型饲料--添加10%脂肪0.5%胆固醇
TP 2R142：兔高脂高胆固醇模型饲料--添加10%脂肪1%胆固醇
TP 2R144：兔高脂高胆固醇模型饲料--添加10%脂肪2%胆固醇
TP 2R148：兔高脂高胆固醇模型饲料--添加11%脂肪1%胆固醇
TP 2R152：兔高脂高胆固醇模型饲料--添加12%脂肪0.1%胆固醇
TP 2R156：兔高脂高胆固醇模型饲料--添加14%脂肪0.05%胆固醇
TP 2R160：兔高脂高胆固醇模型饲料--添加14%脂肪0.5%胆固醇
TP 2R164：兔高脂高胆固醇模型饲料--添加14%脂肪1%胆固醇
如果以上模型饲料不能满足你的研究需要，请提出！
从上述模型饲料列表，我们可以看到：脂肪添加量从3%到14%不等。
那么，脂肪添加量这么大的跨度，怎样选择呢？这是一个技术性很强的问题，请与南通特洛菲饲料科技有限公司咨询和交流，会得到他们耐心的解释和帮助你根据实验目的进行选用。
需要注意的是，上面列表中有两种高脂高胆固醇饲料（代码分别是TP2R112和TP 2R132）添加的是蛋黄粉，其添加量很大，这种添加大量蛋黄粉的方法主要是我国学者喜欢采用，而在国外作者发表的SCI论文中使用罕见，原因是多方面的，选用时需要谨慎。
二、兔高脂肪高胆固醇模型饲料中脂肪类型的确定
不同脂肪在动脉粥样硬化形成和发展的作用及作用的强度不同。应当注意的是，从大量的SCI论文中的调研，发现兔动脉粥样硬化模型的复制和研究中，与大鼠、小鼠等动物的动脉粥样硬化模型饲料很大的区别在于：很多植物油可以用于复制兔动脉粥样硬化模型，或者说，兔对饲料中不同脂肪酸之间比例不合理比较敏感，从而发生动脉粥样硬化。
因此，兔动脉粥样硬化模型饲料中脂肪类型的选择很广，既包括动物脂肪，也包括植物脂肪，既可以是单不饱和脂肪酸高的植物油，也可以是饱和脂肪酸多的植物油。应当根据研究目的进行选择。
在上面的列表中，除了TP2R112和TP 2R132两个代码的模型饲料，其他模型饲料代码都没有明确脂肪类型。那么，怎样确定你所需要的模型饲料及其代码呢？
不同脂肪的编码（部分）
脂肪代码 添加脂肪名称
A—奶油(milkfat, dairy butter)
B—可可脂(cocoa butter)
C—牛油(beef fat)
D—猪油(lard, pork fat)
E—氢化椰子油(hydrogenated coconut oil)
F—氢化棕榈油(hydrogenated palm oil)
G—玉米油(corn oil)
H—花生油(peanut oil，groundnut oil)
上表中列出的是南通特洛菲饲料科技有限公司对脂肪的编号字母。根据你所希望使用的脂肪，从右边中找到相应的编号（字母），然后与上表中你所选择的饲料代码组合起来就是所要的饲料代码。例如，你从前面列表中选择了TP 2R140，所选用的脂肪为奶油（字母A），则你需要的模型饲料是TP2R140A。
当然，如果你的研究需要添加其他特殊类型的脂肪，或者，你需要添加特定比例的不同脂肪酸，请联系该公司。
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