用于建立动脉粥样硬化模型的
兔高胆固醇模型饲料
Atherosclerosis model Diets with High Cholesterol for Rabbit

在“兔动脉粥样硬化模型饲料和模型建立方法”中已经介绍了兔高脂肪、高胆固醇模型饲料在兔动脉粥样硬化模型建立中的使用。这里进一步介绍的兔高脂高胆固醇模型饲料的选用。

一、兔动脉粥样硬化模型高胆固醇模型饲料介绍

兔吸收胆固醇能力强，清除血浆胆固醇的能力差，因此，血浆胆固醇可以维持在高水平。兔对脂肪代谢能力差，容易形成高血脂，引起脂质代谢紊乱，从而发生动脉粥样硬化。

上表列出的是南通特洛菲饲料科技有限公司提供的可用于兔动脉粥样硬化模型建立的高胆固醇饲料。要注意的是，这些模型饲料中胆固醇含量跨度很大，适用于动脉粥样硬化模型和动脉粥样硬化并发症等的使用。那么，怎样确定饲料中胆固醇含量呢？请继续往下阅读。

二、兔高胆固醇模型饲料中胆固醇含量应当多高

(1)要明白人群中高胆固醇膳食的大致水平，换算成兔每天胆固醇摄入量，再根据兔每天饲料摄入量就可以知道兔高胆固醇模型饲料中胆固醇含量应当所处的大致水平。

(2)兔血浆胆固醇升高的原因是血浆胆固醇累积性升高。

因此，模型饲料中胆固醇含量应当考虑血浆胆固醇升高的程度。

模型饲料中胆固醇越高，血浆胆固醇升高越快、但升高的幅度也更大。因此，饲料中胆固醇含量过高，血浆胆固醇水平也会更高，这就容易形成胆固醇毒性。

三、兔高胆固醇模型饲料制作方法 

胆固醇添加量比较小，而胆固醇是不溶于水的有机物，要让少量胆固醇在饲料中分布均匀并不容易。南通特洛菲饲料科技有限公司采取了特殊的加工工艺和技巧。

为了保障胆固醇含量准确，使得实验更为可靠，南通特洛菲饲料科技有限公司对原料严格把关，杜绝伪劣、低纯度胆固醇的原料。

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