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缺钾模型饲料和缺钾造模方法

兔缺钾饲料与缺钾模型(造模)
Low-potassium Diet(LKD)/Potassium-deficient Diet(KD) for Rabbit

兔是食草动物,对饲料中钾的需要量较大(例如,高于鸡,大鼠,小鼠,狗),因而对适度的高钾比较耐受,对缺钾比较敏感,当采用低钾模型饲料(low potassium diet,potassium-deficient diet)喂养后,可快速形成钾剥夺(potassium depletion, KD)或低钾血症(hypokalemia,low blood potassium),因此,兔是比较理想的缺钾造模或低钾血症模型 (hypokalemia rabbit model) 的动物。

兔缺钾后出现食欲下降(摄食量下降),因此,应当根据研究需要决定是否采用配对喂养(Pair-feeding)。当选择钾含量很低的模型饲料时,应当特别注意急性缺钾引起的死亡,关于如果避免该问题,可与南通特洛菲饲料科技有限公司技术部交流。关于其他注意事项,请在“缺钾模型饲料和造模注意事项”中了解。

南通特洛菲饲料科技有限公司生产
兔低钾模型饲料(LK diet)

marker纯化型低钾模型饲料(Purified low potassium diet)

模型饲料代码      钾含量

TP 1R400-004:钾含量约0.004%,即大约1mEq/kg(1 mmol/kg,0.1 mmol/100g)或40ppm; G用于未成年,M用于成年;

TP 1R400-01:钾含量约0.01%,即大约2.6mEq/kg(26 mmol/kg,0.26 mmol/100)或100ppm;G用于未成年,M用于成年;

TP 1R400-1: 钾含量约0.1%,即大约26mEq/kg(26 mmol/kg)或1000ppm;G用于未成年,M用于成年;

TP 1R400-2: 钾含量约0.2%,即大约51mEq/kg(51 mmol/kg)或2000ppm;G用于未成年,M用于成年;

TP 1R400-25:钾含量约0.25%,即大约64mEq/kg(64 mmol/kg)或2500ppm;G用于未成年,M用于成年;

TP 1R400-3: 钾含量约0.3%,即大约77mEq/kg(77 mmol/kg)或3000ppm;G用于未成年,M用于成年;

 TP 1R400: 标准对照饲料。G用于未成年,M用于成年;

如果需要订购其他不同钾含量的缺钾饲料或不同钠含量的模型饲料,请联系我们。

如果没有找到所需要的,请毫不犹豫联系我们。



参考文献:

Guo J, Wang T, Yang T, Xu J, Li W, Fridman MD, Fisher JT, Zhang S. Interaction between the cardiac rapidly (IKr) and slowly (IKs) activating delayed rectifier potassium channels revealed by low K+-induced hERG endocytic degradation.J Biol Chem. 2011 Oct 7;286(40):34664-74. doi: 10.1074/jbc.M111.253351. Epub 2011 Aug 15.

Wingo C. S.(1987) Potassium transport by the medullary collecting tubule of rabbit: effects of variation in K intake. Am. J. Physiol. 253(Renal Fluid Electrolyte Physiol. 22):F1136–F1141

Zhou X., Wingo C. S. (1992) Mechanisms of rubidium permeation by rabbit cortical collecting duct during potassium restriction. Am. J. Physiol. 263(Renal Fluid Electrolyte Physiol. 32):F1134–F1141. 

Yang BC, Li DY, Weng YF, Lynch J, Wingo CS, Mehta JL. Increased superoxide anion generation and altered vasoreactivity in rabbits on low-potassium diet. Am J Physiol Heart Circ Physiol. 1998;274:1955–1961.

Najjar F, Zhou H, Morimoto T, Bruns JB, Li HS, Liu W, Kleyman TR, Satlin LM. Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct.Am J Physiol Renal Physiol. 2005 Oct;289(4):F922-32. Epub 2005 May 24.

Hall RJ, Cameron IR. Effect of chronic dietary potassium depletion and repletion on cardiac and skeletal muscle structure, electrolytes and pH in the rabbit. Clin Sci (Lond). 1981 Apr;60(4):441-9. 

Cameron IR, Hall RJ.Proceedings: The effect of dietary K+ depletion and subsequent repletion on intracellular K+ concentration and pH of cardiac and skeletal muscle in rabbits. J Physiol. 1975 Sep;251(1):70P-71P. 



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